Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB

Chegou Novel N.; Sutherland Jayne S.; Malherbe Stephanus; Crampin Amelia C.; Corstjens Paul L. A. M.; Geluk Annemieke; Mayanja-Kizza Harriet; Loxton Andre G.; van der Spuy Gian; Stanley Kim; Kotze Leigh A.; van der Vyver Marieta; Rosenkrands Ida; Kidd Martin; van Helden Paul D.; Dockrell Hazel M.; Ottenhoff Tom H. M.; Kaufmann Stefan H. E.; Walzl Gerhard

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Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB

机译：七种标志物血清蛋白生物签名在非洲主要医疗诊所参与者中表现出结核病迹象和症状的活动性结核病的诊断性能

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Background User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently needed at points of care in resource-limited settings. We investigated host biomarkers detected in serum samples obtained from adults with signs and symptoms suggestive of TB at primary healthcare clinics in five African countries (Malawi, Namibia, South Africa, The Gambia and Uganda), for the diagnosis of TB disease.

机译：背景技术在资源有限的环境中，在护理点迫切需要用户友好，快速，廉价但准确的结核病诊断工具。我们在五个非洲国家（马拉维，纳米比亚，南非，冈比亚和乌干达）的初级保健诊所调查了从成年人身上发现的具有结核病征兆和症状的血清样本中检测到的宿主生物标志物，以诊断结核病。

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《Thorax: The Journal of the British Thoracic Society》 |2016年第9期|共10页
作者
Chegou Novel N.; Sutherland Jayne S.; Malherbe Stephanus; Crampin Amelia C.; Corstjens Paul L. A. M.; Geluk Annemieke; Mayanja-Kizza Harriet; Loxton Andre G.; van der Spuy Gian; Stanley Kim; Kotze Leigh A.; van der Vyver Marieta; Rosenkrands Ida; Kidd Martin; van Helden Paul D.; Dockrell Hazel M.; Ottenhoff Tom H. M.; Kaufmann Stefan H. E.; Walzl Gerhard;
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正文语种 eng
中图分类呼吸系及胸部疾病;
关键词
Tuberculosis;

机译：结核;

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1. Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB [J] . Chegou Novel N., Sutherland Jayne S., Malherbe Stephanus, Thorax: The Journal of the British Thoracic Society . 2016,第9期

机译：七种标志物血清蛋白生物签名在非洲主要医疗诊所参与者中表现出结核病迹象和症状的活动性结核病的诊断性能
2. Implementation and Operational Research: What Happens After a Negative Test for Tuberculosis? Evaluating Adherence to TB Diagnostic Algorithms in South African Primary Health Clinics [J] . McCarthy K. M., Grant A. D., Chihota V., JAIDS: Journal of acquired immune deficiency syndromes . 2016,第5期

机译：实施和运筹学：结核病阴性检测后会发生什么？评估南非初级卫生诊所对结核病诊断算法的依从性
3. Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation [J] . Anil Pooran, Grant Theron, Lynn Zijenah, The Lancet Global Health . 2019,第6期

机译：非洲南部初级保健诊所Xpert MTB / RIF与涂片显微镜诊断结核的诊断要点：多中心经济评估
4. Patient retention at key milestones after HIV diagnosis at a primary healthcare clinic offering early antiretroviral therapy initiation in Johannesburg, South Africa. [D] . Clouse, Kate. 2012

机译：在南非约翰内斯堡，一家提供初级抗逆转录病毒治疗的初级保健诊所诊断出艾滋病病毒后，将患者留在关键的里程碑。
5. Impact of Xpert MTB/RIF for TB Diagnosis in a Primary Care Clinic with High TB and HIV Prevalence in South Africa: A Pragmatic Randomised Trial [O] . Helen S. Cox, Slindile Mbhele, Neisha Mohess, 2014

机译：Xpert MTB / RIF对南非高结核病和艾滋病毒患病率的初级保健诊所的结核病诊断的影响：一项实用的随机试验
6. Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB [O] . Chegou, N., Sutherland, J., Malherbe, S., 2016

机译：七种标志物血清蛋白生物印记对非洲初级保健诊所参与者的诊断性能，用于诊断活动性结核病，其症状和体征提示结核病

Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB

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