...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Thorax: The Journal of the British Thoracic Society >Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids. Asthma and Allergy Group.
【24h】

Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids. Asthma and Allergy Group.

机译：尽管经口服和吸入皮质类固醇激素治疗，但患有困难的哮喘患者的呼出气一氧化氮水平增加，并且与症状和疾病严重程度相关。哮喘和过敏小组。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Patients with difficult asthma suffer chronic moderate to severe persistent asthma symptoms despite high doses of inhaled and oral corticosteroid therapy. These patients suffer a high level of treatment and disease related morbidity but little is known about the degree of airway inflammation in these patients. METHODS: Fifty two patients were examined to assess levels of exhaled nitric oxide (NO) as a surrogate marker of inflammatory activity in this condition. From this group, 26 patients were defined with severe symptoms and current physiological evidence of reversible airway obstruction requiring high dose inhaled (> or = 2000 micrograms beclomethasone dipropionate (BDP) equivalent) or oral steroid therapy to maintain disease control. RESULTS: Exhaled NO levels were higher in subjects with difficult asthma (mean 13.9 ppb, 95% CI 9.3 to 18.5) than in normal controls (7.4 ppb, 95% CI 6.9 to 7.8; p < 0.002), but lower than levels in steroid naive mild asthmatics (36.9 ppb, 95% CI 34.6 to 39.3; p < 0.001). Prednisolone treated patients had higher exhaled NO levels than patients only requiring inhaled corticosteroids (17.5 ppb, 95% CI 11.1 to 24.0 versus 7.2 ppb, 95% CI 4.6 to 9.8; p = 0.016), suggesting greater disease severity in this group. Non-compliance with prednisolone treatment was observed in 20% of patients but this did not explain the difference between the treatment groups. Exhaled NO levels were closely correlated with symptom frequency (p = 0.03) and with rescue beta agonist use (p < 0.002), but they did not correlate with lung function. CONCLUSIONS: Exhaled NO may serve as a useful complement to lung function and symptomatology in the assessment of patients with chronic severe asthma, and in the control and rationalisation of steroid therapy in these patients.
机译：背景：尽管吸入和口服糖皮质激素治疗剂量较高，但患有困难哮喘的患者仍患有慢性中度至重度持续性哮喘症状。这些患者遭受高水平的治疗和与疾病相关的发病率，但对这些患者的气道炎症程度了解甚少。方法：对52名患者进行了检查，以评估呼出气一氧化氮（NO）的水平，以作为这种情况下炎症活动的替代指标。从这一组中，有26名患者被定义为具有严重症状和当前生理学证据，可逆性气道阻塞需要高剂量吸入（≥2000微克丙酸倍氯米松（BDP）当量）或口服类固醇疗法以维持疾病控制。结果：哮喘患者的呼出NO水平较高（平均13.9 ppb，95％CI 9.3至18.5），高于正常对照组（7.4 ppb，95％CI 6.9至7.8; p <0.002），但低于类固醇水平幼稚的轻度哮喘患者（36.9 ppb，95％CI 34.6至39.3; p <0.001）。泼尼松龙治疗的患者呼出NO水平高于仅需吸入皮质类固醇的患者（17.5 ppb，95％CI为11.1至24.0，而7.2 ppb，95％CI为4.6至9.8; p = 0.016），表明该组疾病的严重程度更高。在20％的患者中观察到不符合泼尼松龙治疗的情况，但这不能解释治疗组之间的差异。呼出的NO水平与症状发生频率（p = 0.03）和抢救β受体激动剂的使用密切相关（p <0.002），但与肺功能无关。结论：呼出的NO可以作为评估慢性重症哮喘患者肺功能和症状的有效补充，以及这些患者的类固醇治疗的控制和合理化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号