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首页> 外文期刊>Biological Psychology >Do sex hormones influence emotional modulation of pain and nociception in healthy women?
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Do sex hormones influence emotional modulation of pain and nociception in healthy women?

机译：性激素会影响健康女性的疼痛和伤害感受的情绪调节吗？

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摘要

Sex hormones may contribute to inter- and intra-individual differences in pain by influencing emotional modulation of pain and nociception. To study this, a well-validated picture-viewing paradigm was used to assess emotional modulation of pain and the nociceptive flexion reflex (NFR; physiologic measure of nociception) during mid-follicular, ovulatory, and late-luteal phases of the menstrual cycle in healthy normally cycling women (n= 40). Salivary estradiol, progesterone, and testosterone were assessed at each testing session. Emotional modulation of pain/NFR did not differ across menstrual phases, but low estradiol was associated with weaker emotional modulation of NFR (during all phases) and emotional modulation of pain (ovulatory and late-luteal phases). Given evidence that a failure to emotionally modulate pain might be a risk factor for chronic pain, low estradiol may promote chronic pain via this mechanism. However, future research is needed to extend these findings to women with disturbances of pain, emotion, and/or sex hormones.
机译：性激素可通过影响疼痛和伤害感受的情绪调节来促进个体间和个体内的疼痛差异。为了研究这一点，使用了一种经过充分验证的图片浏览范式来评估月经周期的卵泡中期，排卵期和黄体晚期的疼痛和痛觉屈曲反射（NFR;伤害性生理指标）的情绪调节。健康的正常骑自行车女性（n = 40）。在每个测试阶段评估唾液雌二醇，孕酮和睾丸激素。在月经期，疼痛/ NFR的情绪调节没有差异，但是雌二醇水平低与NFR的情绪调节较弱（在所有阶段）和疼痛的情绪调节（排卵期和黄体晚期）有关。给定证据表明无法情绪调节疼痛可能是慢性疼痛的危险因素，低雌二醇可能通过这种机制促进慢性疼痛。但是，需要进一步的研究来将这些发现扩展到疼痛，情绪和/或性激素异常的女性。

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