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首页> 外文期刊>Biological Psychology >The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence
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The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence

机译：从儿时到青春期的儿茶酚-O-甲基转移酶基因（COMT）和认知功能

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摘要

Genetic variation in the catechol-O-methyltransferase gene (COMT) can influence cognitive function, and this effect may depend on developmental stage. Using a large representative British birth cohort, we investigated the effect of COMT on cognitive function (verbal and non-verbal) at ages 8 and 15 years taking into account the possible modifying effect of pubertal stage. Five functional COMT polymorphisms, rs6269, rs4818, rs4680, rs737865 and rs165599 were analysed. Associations between COMT polymorphisms and cognition were tested using regression and latent variable structural equation modelling (SEM). Before correction for multiple testing, COMT rs737865 showed association with reading comprehension, verbal ability and global cognition at age 15 years in pubescent boys only. Although there was some evidence for age- and sex-specific effects of the COMT rs737865 none remained significant after correction for multiple testing. Further studies are necessary in order to make firmer conclusions. (C) 2012 Elsevier B.V. All rights reserved.
机译：儿茶酚-O-甲基转移酶基因（COMT）的遗传变异会影响认知功能，而这种效应可能取决于发育阶段。我们使用一个具有代表性的英国出生队列，研究了COMT对8岁和15岁年龄段认知功能（言语和非言语）的影响，同时考虑了青春期的可能改变作用。分析了五个功能性COMT多态性rs6269，rs4818，rs4680，rs737865和rs165599。使用回归和潜在变量结构方程模型（SEM）测试了COMT多态性与认知之间的关联。在更正多项测试之前，COMT rs737865仅在15岁的青春期男孩中显示出与阅读理解，语言能力和整体认知的关联。尽管有一些证据表明COMT rs737865具有针对年龄和性别的特定影响，但经过多次测试校正后，这些影响均不显着。为了得出更坚定的结论，有必要做进一步的研究。 （C）2012 Elsevier B.V.保留所有权利。

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