...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Theriogenology >Induction of abortion with aglepristone significantly changed the expression of progesterone and estrogen receptors in canine endometrial stromal cells
【24h】

Induction of abortion with aglepristone significantly changed the expression of progesterone and estrogen receptors in canine endometrial stromal cells

机译：用aglepristone诱导流产明显改变犬子宫内膜基质细胞中孕酮和雌激素受体的表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the present study, resorption/abortion was induced between days 25 and 45 of gestation with aglepristone (group IRA, n=10). The aim was to observe the change in the distribution of progesterone (PR) and estrogen receptors (ER), in comparison to a group of spontaneous resorptions/abortions (group SRA, n=5), and a further group of normal healthy pregnant animals, ovariohysterectomized between days 25 and 45 of gestation (controls, n=7). The receptors were assessed by means of immunohistochemistry (IHC) and RT-PCR, at the placental and interplacental sites of the uterine horn as well as in the corpus uteri. Significant differences were observed between the controls on one side and the groups of resorption/abortion on the other side. The total scores of the progesterone receptors (TPR) in the placental and interplacental part of the uterine horn, was significantly lower in the endometrial stromal cells (ESC) of the control group than in those of the SRA- and IRA-group, respectively (placenta: 5.8 vs. 6.5 and 6.7, p<0.01; interplacental sites: 5.6 vs. 6.6 and 6.6, p<0.05). In contrary, the total scores of the estrogen receptors (TER) at interplacental sites and the corpus uteri, respectively, was significantly higher in the myometrial smooth muscle cells (MSMC) and the ESC (p<0.05) of the controls. We therefore conclude, that the here observed differences between groups point to an up-regulation of TPR- and a down-regulation of TER-scores in endometrial stromal cells at different uterine sites during resorption/abortion, which indicates a special role of these cells.
机译：在本研究中，在妊娠的第25天至第45天之间使用aglepristone（IRA组，n = 10）诱导了吸收/流产。与一组自然吸收/中止（SRA组，n = 5）以及另一组正常健康的怀孕动物相比，目的是观察孕酮（PR）和雌激素受体（ER）分布的变化。 ，在妊娠的第25至45天进行卵巢子宫切除术（对照组，n = 7）。通过免疫组化（IHC）和RT-PCR在子宫角和子宫体的胎盘和胎盘部位评估受体。在一侧的对照与另一侧的吸收/流产组之间观察到显着差异。子宫内膜间质细胞（ESC）在子宫角的胎盘和胎盘间部分的孕酮受体（TPR）的总分分别显着低于SRA和IRA组（胎盘：5.8对6.5和6.7，p <0.01;胎盘间部位：5.6对6.6和6.6，p <0.05）。相反，在对照组的肌层平滑肌细胞（MSMC）和ESC中，胎盘部位和子宫体的雌激素受体（TER）的总分分别显着更高。因此，我们得出结论，此处观察到的组间差异表明在子宫内膜间质细胞在吸收/流产过程中子宫内膜基质细胞中TPR的上调和TER的下调，表明这些细胞的特殊作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号