• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis >Plasmatic homocysteine response to vitamin supplementation in elderly people.
【24h】

Plasmatic homocysteine response to vitamin supplementation in elderly people.

机译：血浆高半胱氨酸对老年人补充维生素的反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Homocysteine (Hcy) increase is now widely accepted as a risk factor for vascular disease. The effects of folic acid (FA) and vitamins B12 and B6 in lowering Hcy have been extensively studied, but there is still little data on the response to FA dietary administration. Our purpose was to evaluate the impact of the diet and the degree of response to different doses of pharmacological FA supplementation. In a prospective, randomized, and simple blind study, 50 elderly subjects were given a 400-microg/day FA diet and were randomly assigned to one of the following treatments: Group I = placebo tablet; Group II = tablet containing 1-mg folic acid, 1-mg B12, and 25-mg B6; and Group III = tablet containing 2.5-mg folic acid and same B6 and B12 doses as Group II. Forty-four subjects completed the study, and their plasmas were evaluated. Hcy concentration significantly decreased even in patients with normal basal values, and there were no differences in the response between individuals receiving diet plus placebo and those receiving diet plus pharmacological supplementation. After the treatment, the mean decrease of plasmatic Hcy levels was 10.8 (9.4, 12.5) micromol/l, geometric mean [95% confidence interval (95% CI)], and particularly, the values for Group I were 10.6 (7.4, 14.8) micromol/l. In 31% of the subjects, the post-treatment Hcy levels were less than or = 5 micromol/l. These results show that a special diet, with or without pharmacological FA and B12 and B6 supplementation, significantly decreases the Hcy levels in elderly people. Therefore, a diet with high contents of FA might have an enormous impact on the morbidity and mortality of atherothrombosis.
机译：同型半胱氨酸（Hcy）的增加已被广泛认为是血管疾病的危险因素。叶酸（FA）和维生素B12和B6降低Hcy的作用已被广泛研究，但对FA饮食管理的反应仍缺乏数据。我们的目的是评估饮食的影响以及对不同剂量药理FA补充剂的反应程度。在一项前瞻性，随机且简单的盲法研究中，对50位老年受试者给予400微克/天的FA饮食，并随机分配至以下治疗方法之一：组II =含有1毫克叶酸，1毫克B12和25毫克B6的片剂;第三组=含有2.5毫克叶酸且与第二组相同剂量的B6和B12的片剂。 44名受试者完成了研究，并对其血浆进行了评估。即使在基础值正常的患者中，Hcy浓度也显着降低，并且接受饮食加安慰剂的个体与接受饮食加药理学补充的个体之间的反应无差异。治疗后，血浆Hcy水平的平均下降为10.8（9.4，12.5）micromol / l，几何平均值[95％置信区间（95％CI）]，特别是，I组的值为10.6（7.4，14.8） ）微摩尔/升。在31％的受试者中，治疗后的Hcy水平小于或等于5微摩尔/升。这些结果表明，有或没有药理性FA以及补充B12和B6的特殊饮食会显着降低老年人的Hcy水平。因此，高FA含量的饮食可能对动脉粥样硬化血栓形成的发病率和死亡率产生巨大影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号