Diverse CD36 expression among Japanese population: defective CD36 mutations cause platelet and monocyte CD36 reductions in not only deficient but also normal phenotype subjects

Masuda Yuya; Tamura Shogo; Matsuno Kazuhiko; Nagasawa Ayumi; Hayasaka Koji; Shimizu Chikara; Moriyama Takanori

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Diverse CD36 expression among Japanese population: defective CD36 mutations cause platelet and monocyte CD36 reductions in not only deficient but also normal phenotype subjects

机译：日本人群中CD36的表达多样：缺陷的CD36突变不仅导致缺陷表型受试者，而且导致正常表型受试者的血小板和单核细胞CD36含量降低

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Introduction: CD36 is a multifunctional glycoprotein expressed on various human cells, including platelets and monocytes. Five CD36 gene mutations (C268T, 949insA, 329-339del, 1228-1239del and 629-631del/insAAAAC) are mainly responsible for CD36-deficient phenotypes in Japan. It has also been reported that platelet CD36 expression varies widely among normal phenotype individuals. Here, in order to obtain further insight into CD36 expression, we investigated the association between platelet and monocyte CD36 expression levels and defective mutations in the Japanese population. Materials and

机译：简介：CD36是在多种人类细胞（包括血小板和单核细胞）中表达的多功能糖蛋白。在日本，五个CD36基因突变（C268T，949insA，329-339del，1228-1239del和629-631del / insAAAAC）主要负责CD36缺陷型。还已经报道，正常表型个体之间血小板CD36的表达差异很大。在这里，为了获得对CD36表达的进一步了解，我们研究了血小板和单核细胞CD36表达水平与日本人群中的缺陷突变之间的关系。材料和

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来源
《Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis》 |2015年第5期|共7页
作者
Masuda Yuya; Tamura Shogo; Matsuno Kazuhiko; Nagasawa Ayumi; Hayasaka Koji; Shimizu Chikara; Moriyama Takanori;
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正文语种 eng
中图分类神经病学;
关键词
CD36 molecule expression; CD36 deficiency; gene polymorphisms; platelets; monocytes;

机译：CD36分子表达;CD36缺陷;基因多态性;血小板;单核细胞;

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1. Diverse CD36 expression among Japanese population: defective CD36 mutations cause platelet and monocyte CD36 reductions in not only deficient but also normal phenotype subjects [J] . Masuda Yuya, Tamura Shogo, Matsuno Kazuhiko, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2015,第5期

机译：日本人群中CD36的表达多样：缺陷的CD36突变不仅导致缺陷表型受试者，而且导致正常表型受试者的血小板和单核细胞CD36含量降低
2. Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. [J] . Ruiz Velasco N, Vega MA Biochemical Pharmacology . 2004,第2期

机译：他汀类药物上调人单核细胞中CD36的表达，与PPAR-γ配体结合后，这种作用增强。RhoGTPases在他汀类药物诱导的CD36表达中的推定作用。
3. Analyses of genetic abnormalities in type I CD36 deficiency in Japan: identification and cell biological characterization of two novel mutations that cause CD36 deficiency in man. [J] . Kashiwagi H, Tomiyama Y, Nozaki S, Human Genetics . 2001,第6期

机译：在日本的I型CD36缺乏症的遗传异常分析：鉴定和两个导致人类CD36缺乏症的新突变的细胞生物学特性。
4. Effects of Ginkgo Biloba Extract on Cellular Cholesterol Content and CD36 Expression of Macrophages from Diabetic Rats [C] . Li Xusheng, Ji Lanfang, Fu Yongqiang, Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on . 2012

机译：银杏叶提取物对糖尿病大鼠细胞内胆固醇含量和巨噬细胞CD36表达的影响
5. Role of CD36 in platelet function. [D] . Ghosh, Arunima. 2007

机译：CD36在血小板功能中的作用。
6. Variants of CD36 gene and their association with CD36 protein expression in platelets [O] . Xianguo Xu, Ying Liu, Xiaozhen Hong, 2014

机译：CD36基因的变异及其与血小板中CD36蛋白表达的关系
7. Oxidized LDL–Induced NF-κB Activation and Subsequent Expression of Proinflammatory Genes Are Defective in Monocyte-Derived Macrophages From CD36-Deficient Patients [O] . Mohamed Janabi, Shizuya Yamashita, Ken-ichi Hirano, 2000

机译：氧化的LDL诱导的NF-κB活化和后续炎性基因的表达在来自CD36缺陷患者的单核细胞衍生的巨噬细胞中有缺陷
8. Antibodies Against Human Cell Receptors, CD36, CD41a, and CD62P Crossreact With Porcine Platelets. [R] . Delgado, A. V., Alexander, S. L., McManus, A. T., 2003

机译：针对人细胞受体的抗体，CD36，CD41a和CD62p与猪血小板交叉反应。

Diverse CD36 expression among Japanese population: defective CD36 mutations cause platelet and monocyte CD36 reductions in not only deficient but also normal phenotype subjects

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