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首页> 外文期刊>Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy >Preparation of Cu2+-loaded porous chitosan particles for immunoglobulin G adsorption.
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Preparation of Cu2+-loaded porous chitosan particles for immunoglobulin G adsorption.

机译：负载Cu2 +的多孔壳聚糖颗粒的制备，用于免疫球蛋白G的吸附。

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摘要

Chitosan porous particles were prepared using a precipitation technique. The porous particles could bind Cu(2+), from which Cu(2+)-loaded porous particles were prepared. The Cu(2+)-loaded porous chitosan particles could remove immunoglobulin (Ig) G more selectively than albumin, IgA and IgM from aqueous solutions and human plasma. The effect of the volume ratio of plasma to particles on protein adsorption was studied, with the results indicating that a volume ratio of 3:1 might be a good choice for clinical use. The particles could be easily incorporated into a column. When human plasma was applied to the particle column, higher removal efficiency was obtained. These results suggested that Cu(2+)-loaded porous particles may be a potentially good sorbent for IgG removal from plasma.
机译：使用沉淀技术制备壳聚糖多孔颗粒。多孔颗粒可以结合Cu（2+），由此制备负载Cu（2+）的多孔颗粒。 Cu（2+）负载的多孔壳聚糖颗粒可以比水溶液和人血浆中的白蛋白，IgA和IgM更有选择性地去除免疫球蛋白（Ig）G。研究了血浆与颗粒的体积比对蛋白质吸附的影响，结果表明3：1的体积比可能是临床应用的不错选择。颗粒可以容易地结合到柱中。当将人血浆应用于颗粒柱时，可获得更高的去除效率。这些结果表明，负载Cu（2+）的多孔颗粒可能是从血浆中去除IgG的潜在良好吸附剂。

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