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Development of regional chemotherapies: feasibility, safety and efficacy in clinical use and preclinical studies

机译:区域化学疗法的发展:在临床使用和临床前研究中的可行性,安全性和有效性

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The most common types of cancer therapies include surgery, radiation, chemotherapy and their combinations. In the past decades, new treatment regimens have been discovered and implemented in the clinic, to concurrently or successively complement the standard procedures in cancer therapy, and provide patients with improved treatment outcomes with fewer side effects. Some of these clinical and inves-tigational treatment methods include: anti-angiogenesis therapy [1-3], immunotherapy [4-6], gene therapy [7-9], bone marrow transplantation and peripheral blood stem-cell transplantation [10-12]. Owing to the complex nature of the molecular targets of these newer therapies and their relatively short history since clinical introduction, they are not as widely used as conventional chemotherapy and are substantially more expensive.
机译:癌症治疗的最常见类型包括手术,放射线,化学疗法及其组合。在过去的几十年中,已经在临床中发现并实施了新的治疗方案,以同时或相继补充癌症治疗中的标准程序,并为患者提供改善的治疗结果且副作用更少。这些临床和研究治疗方法包括:抗血管生成治疗[1-3],免疫治疗[4-6],基因治疗[7-9],骨髓移植和外周血干细胞移植[10- 12]。由于这些较新疗法的分子靶标的复杂性质以及自临床引入以来相对较短的历史,它们没有像常规化学疗法那样广泛使用,并且价格昂贵得多。

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