Cancer cell spheroids for screening of chemotherapeutics and drug-delivery systems

CenterforPharmaceuticalBiotechnologyandNanomedicineNortheasternUniversity; NemucoreMedicalInnovationsInc.; DepartmentofBiochemistryFacultyofScience; NationalInstituteofStandardsandTechnologyGaithersberg

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Cancer cell spheroids for screening of chemotherapeutics and drug-delivery systems

机译：癌细胞球体，用于筛选化学疗法和药物传递系统

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Over the last few decades, the most popular platform to perform high-throughput screening for viable anti-neoplastic compounds has been monolayer cell culture. However, cells in monolayer culture lose many of their in vivo characteristics. As a result, this platform provides a limited predictive value in determining the clinical outcome of the compounds of interest. Using a technique known as 3D spheroid culture, may be the answer to this conundrum. Spheroids have been shown to mimic the tissue-like properties of tumors necessary for the proper evaluation of compounds. In this review, production of cancer cell spheroids, utilization of these spheroids in understanding various therapeutic mechanisms and the potential for their use in high-throughput screening of drugs and drug-delivery systems are discussed in detail.

机译：在过去的几十年中，用于进行高通量筛选可行的抗肿瘤化合物的最流行平台是单层细胞培养。但是，单层培养中的细胞失去了许多体内特性。结果，该平台在确定目标化合物的临床结果方面提供了有限的预测价值。使用称为3D球体培养的技术可能是解决这个难题的答案。球体已被证明可模仿正确评估化合物所需的肿瘤组织样特性。在这篇综述中，将详细讨论癌细胞球体的生产，这些球体在理解各种治疗机制中的利用以及它们在药物和药物传递系统的高通量筛选中的应用潜力。

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《Therapeutic delivery》 |2015年第4期|共12页
作者
CenterforPharmaceuticalBiotechnologyandNanomedicineNortheasternUniversity; NemucoreMedicalInnovationsInc.; DepartmentofBiochemistryFacultyofScience; NationalInstituteofStandardsandTechnologyGaithersberg;
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1. Cancer cell spheroids for screening of chemotherapeutics and drug-delivery systems [J] . CenterforPharmaceuticalBiotechnologyandNanomedicineNortheasternUniversity, NemucoreMedicalInnovationsInc., DepartmentofBiochemistryFacultyofScience, Therapeutic delivery . 2015,第4期

机译：癌细胞球体，用于筛选化学疗法和药物传递系统
2. Microporous cellulosic scaffold as a spheroid culture system modulates chemotherapeutic responses and stemness in hepatocellular carcinoma [J] . Wu Guoyi, Zhan Shanshan, Rui Chen, Journal of cellular biochemistry. . 2019,第4期

机译：作为球状培养系统的微孔纤维素支架调节肝细胞癌的化疗反应和茎秆
3. Hypoxia Responsive, Tumor Penetrating Lipid Nanoparticles for Delivery of Chemotherapeutics to Pancreatic Cancer Cell Spheroids [J] . Kulkarni Prajakta, Haldar Manas K., Katti Preeya, Bioconjugate Chemistry . 2016,第8期

机译：缺氧反应性，肿瘤穿透脂质纳米颗粒的化学疗法传递给胰腺癌细胞球体。
4. An integrated microfluidic system for screening of peptides specific to colon cancer cells and colon cancer stem cells using the phage display technology [C] . Che Yu-Jui, Wu Huei-Wen, Hung Lein-Yu, IEEE International Conference on Nano/Micro Engineered and Molecular Systems . 2014

机译：使用噬菌体展示技术，用于筛选结肠癌细胞和结肠癌干细胞特异肽的集成微流系统
5. Experimental chemotherapeutic approaches in solid tumor spheroids of gastro-intestinal cell lines using the chemotherapeutic drug gemcitabine-HCl (Gemzar(TM)) and the cyclooxygenase inhibitor rofecoxib (Vioxx(TM)). [D] . Intrieri, Gino. 2003

机译：使用化疗药物吉西他滨-HCl（Gemzar™）和环加氧酶抑制剂罗非考昔（Vioxx™）在胃肠道细胞系的实体肿瘤球体中进行实验性化学疗法。
6. Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment [O] . Daniel S. Reynolds, Kristie M. Tevis, William A. Blessing, -1

机译：乳腺癌球体揭示了对化学疗法的不同的癌症干细胞反应。
7. A more aggressive breast cancer spheroid model coupled to an electronic capillary sensor system for a high-content screening of cytotoxic agents in cancer therapy: 3-dimensional in vitro tumor spheroids as a screening model [O] . Bartholomä, P., Impidjati, Reininger-Mack, A., 2005

机译：更具侵略性的乳腺癌球体模型与电子毛细管传感器系统相结合，用于癌症治疗中细胞毒性剂的高含量筛选：三维体外肿瘤球体作为筛选模型

Cancer cell spheroids for screening of chemotherapeutics and drug-delivery systems

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