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首页> 外文期刊>Tissue antigens. >A single-nucleotide polymorphism marker within the FCRL5 gene and HLA-B27 positive Han Chinese ankylosing spondylitis patients.
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A single-nucleotide polymorphism marker within the FCRL5 gene and HLA-B27 positive Han Chinese ankylosing spondylitis patients.

机译：FCRL5基因和HLA-B27阳性汉族强直性脊柱炎患者中的单核苷酸多态性标记。

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摘要

The aim of this study was to determine whether FCRL5 genes in concert with human leukocyte antigen-B27 (HLA-B27) genotypes are associated with susceptibility to ankylosing spondylitis (AS) in Chinese population. One hundred and sixty-nine HLA-B27-positive AS patients (107 males and 62 females) and 184 HLA-B27-positive matched controls (112 males and 72 females) were analyzed from Han Chinese populations by case-control design, and their samples were genotyped using a panel of two single-nucleotide polymorphism (SNP) markers (rs6427384, rs12036228) within the FCRL5 gene by ligase detection reactions (LDRs) and the HLA-B27 subtypes were determined by polymerase chain reaction (PCR) using sequence-specific primer (SSP) methods. Our results show that in addition to B27, the SNPs rs6427384 and rs12036228 were associated with AS, and the C-T haplotype was higher in cases with AS than in the control population [74.8% vs 63.6%, Fisher's P = 0.003, odds ratio (OR) = 1.660,95% confidence interval (CI) = 1.184-- 2.326]. Our results suggest that, in addition to HLA-B27, a novel polymorphism within the FCRL5 gene confers susceptibility to AS in Han Chinese population.
机译：这项研究的目的是确定与人白细胞抗原-B27（HLA-B27）基因型一致的FCRL5基因是否与中国人群对强直性脊柱炎（AS）的敏感性相关。通过病例对照设计，从汉族人群中分析了169例HLA-B27阳性AS患者（107例男性和62例女性）和184例HLA-B27阳性匹配对照（112例男性和72例女性），并对其进行了分析。通过连接酶检测反应（LDR），使用FCRL5基因内的两个单核苷酸多态性（SNP）标记（rs6427384，rs12036228）进行基因分型，并通过聚合酶链反应（PCR）使用序列-确定HLA-B27亚型特定引物（SSP）方法。我们的结果表明，除了B27外，SNP rs6427384和rs12036228与AS相关，并且AS病例的CT单倍型高于对照组[74.8％vs 63.6％，Fisher's P = 0.003，优势比（OR ）= 1.660,95％置信区间（CI）= 1.184-- 2.326]。我们的结果表明，除了HLA-B27外，FCRL5基因内的一种新的多态性使汉族人群对AS易感。

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