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首页> 外文期刊>Tissue antigens. >Association between single nucleotide polymorphisms of surfactant protein D and allergic rhinitis in Chinese patients.
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Association between single nucleotide polymorphisms of surfactant protein D and allergic rhinitis in Chinese patients.

机译：中国患者表面活性剂蛋白D单核苷酸多态性与变应性鼻炎的关系。

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摘要

The development of allergic rhinitis is considered to be determined by the interaction between genetic and environmental factors. Surfactant protein D (SP-D) has been proposed to offer protection against allergenic challenge at various levels in allergic responses. The present study aimed to investigate whether polymorphisms within the SFTPD gene (Met11Thr, Ala160Thr, and Ser270Thr) are associated with allergic rhinitis. Genotyping of SFTPD polymorphisms was performed using the pyrosequencing method. The study population comprised 216 patients with allergic rhinitis and 84 normal controls. The frequency of 11Thr/Thr genotype and Thr allele in the patient group was significantly higher than that in the control group after applying Bonferroni corrections (P = 0.007 and P = 0.006, respectively). Our subjects with the 11Thr/Thr genotype are more susceptible to allergic rhinitis. There were no significant differences between the patient group and the control group for frequencies of genotypes and alleles in either Ala160Thr or Ser270Thr single nucleotide polymorphisms (P > 0.05). No significant associations could be detected between any of these three SFTPD gene polymorphisms and the skin prick test response (P > 0.05). Meanwhile, there was a lack of association between the three loci and the levels of serum total immunoglobulin E (P > 0.05). In summary, our results suggest that the Met11Thr polymorphism in SP-D plays a major role in the genetic predisposition to allergic rhinitis in Chinese adult population, whereas the other two SP-D polymorphisms displayed no significant association with allergic rhinitis.
机译：过敏性鼻炎的发生被认为是由遗传和环境因素之间的相互作用决定的。已经提出表面活性剂蛋白D（SP-D）可以在不同程度的过敏反应中提供针对变应原性攻击的保护。本研究旨在调查SFTPD基因（Met11Thr，Ala160Thr和Ser270Thr）内的多态性是否与过敏性鼻炎有关。 SFTPD多态性的基因分型使用焦磷酸测序法进行。研究人群包括216名过敏性鼻炎患者和84名正常对照。应用Bonferroni校正后，患者组中11Thr / Thr基因型和Thr等位基因的频率显着高于对照组（分别为P = 0.007和P = 0.006）。我们的11Thr / Thr基因型的受试者更易患过敏性鼻炎。在患者组和对照组之间，Ala160Thr或Ser270Thr单核苷酸多态性的基因型和等位基因频率没有显着差异（P> 0.05）。这三个SFTPD基因多态性与皮肤点刺试验反应之间均未发现显着相关性（P> 0.05）。同时，这三个基因座与血清总免疫球蛋白E水平之间缺乏关联（P> 0.05）。总之，我们的结果表明，SP-D中的Met11Thr多态性在中国成人人群过敏性鼻炎的遗传易感性中起主要作用，而其他两个SP-D多态性与过敏性鼻炎没有显着相关性。

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