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首页> 外文期刊>Tissue engineering >Mechano-Active Scaffold Design Based on Microporous Poly(L-lactide-co-e-caprolactone) for Articular Cartilage Tissue Engineering: Dependence of Porosity on Compression Force-Applied Mechanical Behaviors
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Mechano-Active Scaffold Design Based on Microporous Poly(L-lactide-co-e-caprolactone) for Articular Cartilage Tissue Engineering: Dependence of Porosity on Compression Force-Applied Mechanical Behaviors

机译：基于微孔聚（L-丙交酯-co-ε-己内酯）的关节软骨组织工程的机械主动支架设计：孔隙率对压缩力施加的机械行为的依赖性

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摘要

An essential component of functional articular cartilage tissue engineering is a mechano-active scaffold, which responds to applied compression stress and causes little permanent deformation. As the first paper of a series on mechano-active scaffold-based cartilage tissue engineering, this study focused on mechanical responses to various modes of loading of compression forces and subsequent selection of mechano-active scaffolds from the biomechanical viewpoint. Scaffolds made of elas-tomeric microporous poly(L-lactide-co-epsilon-caprolactone) (PLCL) with open-cell structured pores (300 ~ 500 mum) and with different porosities ranging from 71 to 86% were used. The PLCL sponges and rabbit articular cartilage tissue were subjected to compression/unloading tests (0.1 and 0.005 Hz) at 5 kPa, and stress relaxation tests at 10, 30, and 50% strain. The measurements of the maximum strain under loading and residual strain under unloading for compression tests and the maximum stress and equilibrium stress in the stress relaxation test showed that the lower the porosity, the closer the mechanical properties are to those of native cartilage tissue. Among the PLCL sponges, the sponge with 71 % porosity appears to be a suitable cartilage scaffold.
机译：机械关节支架是功能性关节软骨组织工程的重要组成部分，它可以对施加的压力产生响应，并且几乎不会产生永久变形。作为有关基于机械活性支架的软骨组织工程的系列文章的第一篇，本研究着重于对各种压力模式加载的机械响应以及从生物力学角度对机械活性支架的后续选择。使用由弹性体微孔聚（L-丙交酯-ε-己内酯）（PLCL）制成的支架，该支架具有开孔结构的孔（300〜500 mum），孔隙率范围为71％至86％。对PLCL海绵和兔关节软骨组织进行5 kPa的压缩/卸载测试（0.1和0.005 Hz），并在10％，30％和50％应变下进行应力松弛测试。压缩试验中加载时的最大应变和卸载时的残余应变以及应力松弛测试中的最大应力和平衡应力的测量结果表明，孔隙率越低，其机械性能就越接近天然软骨组织。在PLCL海绵中，孔隙率为71％的海绵似乎是合适的软骨支架。

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