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首页> 外文期刊>Thyroid: official journal of the American Thyroid Association >Diagnostic utility of thyroglobulin detection in fine-needle aspiration of cervical cystic metastatic lymph nodes from papillary thyroid cancer with negative cytology.
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Diagnostic utility of thyroglobulin detection in fine-needle aspiration of cervical cystic metastatic lymph nodes from papillary thyroid cancer with negative cytology.

机译：甲状腺球蛋白检测在细针穿刺甲状腺乳头状癌的宫颈囊性转移性淋巴结细针穿刺细胞学检查中的诊断作用。

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摘要

Cystic changes in metastatic cervical lymph nodes (CLN) from papillary thyroid cancer (PTC) may be a diagnostic pitfall in fine-needle aspiration biopsy (FNAB) cytology. We investigated in a series of CLN metastases from thyroid cancers (TC), including cystic PTC, and from a wide spectrum of extrathyroidal malignancies, the diagnostic role for metastatic TC of the rapid detection of thyroglobulin in eluates from FNAB (FNAB-Tg) of CLN. The study was carried out in a group of 79 subjects (22/57 M/F; median age, 56 years; range, 20-86 years) with enlarged CLN and thyroid nodules (TN), examined for potential metastatic TC, and harboring a large spectrum of incidentally diagnosed extrathyroidal malignancies (n = 24, mostly represented by lymphomas, lung, and breast cancers), CLN metastases from thyroid cancers (n = 28, including 6 cystic metastatic PTC), 6 specific lymphadenitis and 21 reactive lymphadenitis mostly detected (n = 16) during follow-up of patients with previously ablated TC. Markedly high FNABthyroglobulin (Tg) values were found in all metastatic CLN TC. Two of the six cases with cystic metastatic CLN PTC were diagnosed by FNAB-Tg but not by cytology. In conclusion, FNAB-Tg has been confirmed as an easy modality and fast procedure to diagnose CLN metastasis from TC and high FNAB-Tg values with nondiagnostic cystic cytology strongly suggest cystic metastatic PTC.
机译：乳头状甲状腺癌（PTC）转移性颈淋巴结（CLN）的囊性变化可能是细针穿刺活检（FNAB）细胞学的诊断陷阱。我们调查了甲状腺癌（TC）的一系列CLN转移，包括囊状PTC，以及广泛的甲状腺外恶性肿瘤，从FNAB（FNAB-Tg）洗脱液中快速检测甲状腺球蛋白对转移性TC的诊断作用。 CLN。这项研究是在79名受试者（22/57 M / F;中位年龄为56岁;范围为20-86岁）中进行的，这些受试者的CLN和甲状腺结节（TN）增大，检查了潜在的转移性TC，大量偶然诊断出的甲状腺外恶性肿瘤（n = 24，主要表现为淋巴瘤，肺癌和乳腺癌），甲状腺癌的CLN转移（n = 28，包括6个囊性转移性PTC），6个特异性淋巴结炎和21个反应性淋巴结炎在对先前已消融的TC患者进行随访期间检测到（n = 16）。在所有转移性CLN TC中均发现FNAB甲状腺球蛋白（Tg）值明显较高。在6例囊性转移性CLN PTC病例中，有2例通过FNAB-Tg诊断，但未通过细胞学诊断。总之，已确认FNAB-Tg是一种从TC诊断CLN转移的简便方法和快速程序，并且具有高FNAB-Tg值且不能诊断出囊性细胞学，强烈提示囊性转移性PTC。

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