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首页> 外文期刊>Thyroid: official journal of the American Thyroid Association >The cytological, clinical, and pathological features of the cribriform-morular variant of papillary thyroid carcinoma and mutation analysis of CTNNB1 and BRAF genes.
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The cytological, clinical, and pathological features of the cribriform-morular variant of papillary thyroid carcinoma and mutation analysis of CTNNB1 and BRAF genes.

机译：乳头状甲状腺癌筛状-筛状变体的细胞学，临床和病理学特征以及CTNNB1和BRAF基因的突变分析。

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BACKGROUND: The cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) is an unusual subtype of papillary thyroid carcinoma. The goal of this study was to determine the clinicopathological features of CMVPTC and whether the tumor can be diagnosed by fine-needle aspiration cytology. METHODS: We retrospectively analyzed the clinical appearance and pathological findings in five patients with CMVPTC and sequenced exon 3 of CTNNB1 and exon 15 of BRAF in tumor tissue. RESULTS: All patients were young women, 15-34 years of age at the time of the cancer diagnosis. Preoperative cytological examination showed scattered tall columnar cells, fascicular spindle cells, and cribriform and morular patterns in the fine-needle aspirates of the thyroid from the five patients. Grossly, all tumors were well-circumscribed, solid or cystic. Immunohistochemically, most tumor cells showed nuclear expression of thyroid transcription factor-1, estrogen and progesterone receptors, and p53; cytoplasmic expression of cytokeratins 7 and 19, vimentin, and bcl-2; and cytoplasmic and nuclear accumulation of beta-catenin and galectin-3. There was no expression of thyroglobulin, cytokeratin 5/6, or human mesothelial cell-1. However, among these markers, the morular cells showed only positive immunostaining for beta-catenin, galectin-3, p53, and bcl-2. A CTNNB1 mutation was identified in only one case and no BRAF mutation was found in any of the five cases. CONCLUSIONS: Taken together, these data suggest that CMVPTC can be diagnosed preoperatively, based on careful cytology examination, and shows unique immunohistochemical findings.
机译：背景：乳头状甲状腺癌的筛状-砂质变型是乳头状甲状腺癌的一种罕见亚型。这项研究的目的是确定CMVPTC的临床病理特征，以及是否可以通过细针穿刺细胞学检查来诊断肿瘤。方法：我们回顾性分析了5例CMVPTC患者的临床表现和病理结果，并对肿瘤组织中CTNNB1的外显子3和BRAF的外显子15进行了测序。结果：所有患者均为癌症诊断时15-34岁的年轻女性。术前细胞学检查显示五名患者的甲状腺细针抽吸物中散布着高大的柱状细胞，束状梭形细胞以及筛状和桑树样的形态。总体而言，所有肿瘤均界限清楚，为实性或囊性。免疫组织化学分析，大多数肿瘤细胞显示出甲状腺转录因子-1，雌激素和孕激素受体以及p53的核表达。细胞角蛋白7和19，波形蛋白和bcl-2的胞质表达;和β-catenin和galectin-3的胞质和核积累。没有甲状腺球蛋白，细胞角蛋白5/6或人间皮细胞1的表达。但是，在这些标记中，桑蚕细胞仅对β-catenin，galectin-3，p53和bcl-2呈阳性免疫染色。仅在一例中发现了CTNNB1突变，而五例中均未发现BRAF突变。结论：综上所述，这些数据表明，基于仔细的细胞学检查，可以在术前诊断CMVPTC，并显示出独特的免疫组化发现。

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