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首页> 美国卫生研究院文献>Oncology Letters >Association analysis and the clinical significance of BRAF gene mutations and ultrasound features in papillary thyroid carcinoma
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Association analysis and the clinical significance of BRAF gene mutations and ultrasound features in papillary thyroid carcinoma

机译：甲状腺乳头状癌BRAF基因突变与超声特征的关联分析及其临床意义

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The aim of the present study was to evaluate the associations between the B-Raf proto-oncogene serine/threonine kinase (BRAF)V600E mutation and conventional and contrast-enhanced ultrasonographic features in patients with papillary thyroid carcinoma (PTC), and to subsequently investigate the clinical value of these associations. In total, 207 thyroid nodules (diameter ≤2 cm) were selected. Conventional ultrasound, contrast-enhanced ultrasound, BRAFV600E mutational analysis and ultrasound-guided fine-needle aspiration biopsy were preoperatively performed, and histopathological assessment of PTC was postoperatively confirmed. The nodules were divided into 2 groups based on the BRAFV600E mutational analysis, namely the mutant or the wild-type variant groups, and the association analyses of the ultrasonographic features between these 2 groups were performed. Overall, 74.9% (155/207) of the PTC nodules had the BRAFV600E mutation, while 25.1% (52/207) had the wild-type BRAF allele. The 2 groups were analyzed using univariate logistic regression analysis, which demonstrated no significant differences regarding morphology, boundary, hypoechogenicity of the nodules, blood flow signal, enhancement uniformity, enhancement degree and clearance time (P>0.05). Moreover, the 2 groups demonstrated significant differences regarding the aspect ratio, microcalcification, nodule size following enhancement, enhancement mode and enhancement time (P<0.05). A multivariate logistic regression analysis was performed to further validate the association of these features with the BRAFV600E mutation; however, only microcalcification [odds ratio (OR), 2.256; 95% confidence interval (CI), 1.160–5.500; P=0.020] and nodule size following enhancement (OR, 2.119; 95% CI, 1.039–4.321; P=0.039) were associated with the BRAF mutational status. The associations found between the two ultrasonographic features and BRAFV600E mutation indicate that they can predict the BRAF mutational status to provide a reliable basis for clinical diagnosis and treatment.
机译：本研究的目的是评估乳头状甲状腺癌（PTC）患者的B-Raf原癌基因丝氨酸/苏氨酸激酶（BRAF）V600E突变与常规和超声造影特征之间的关联，并进行后续研究这些协会的临床价值。总共选择了207个甲状腺结节（直径≤2 cm）。术前进行常规超声，对比增强超声，BRAFV600E突变分析和超声引导下细针穿刺活检，并在术后确认PTC的组织病理学评估。根据BRAFV600E突变分析将结节分为两组，即突变组或野生型变异组，并对这两组之间的超声特征进行关联分析。总体而言，PTC结节中有74.9％（155/207）具有BRAFV600E突变，而野生型BRAF等位基因则占25.1％（52/207）。两组采用单因素逻辑回归分析，结节形态，边界，结节性降低，血流信号，增强均匀性，增强程度和清除时间无显着性差异（P> 0.05）。此外，两组在长宽比，微钙化，增强后结节大小，增强模式和增强时间方面均表现出显着差异（P <0.05）。进行了多元logistic回归分析，以进一步验证这些特征与BRAFV600E突变的关联。但是，只有微钙化[比值比（OR）为2.256； 95％置信区间（CI），1.160-5.500； P = 0.020]和增强后的结节大小（OR，2.119； 95％CI，1.039-4.321； P = 0.039）与BRAF突变状态有关。这两个超声特征与BRAFV600E突变之间的关联表明，它们可以预测BRAF突变状态，从而为临床诊断和治疗提供可靠的基础。

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