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Association between the BRAF V600E mutation and ultrasound features of the thyroid in thyroid papillary carcinoma

机译：甲状腺乳头状癌的甲状腺BRAF V600E突变与超声特征之间的关联

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摘要

The aim of the present study was to investigate the association between the BRAF V600E mutation and ultrasound features of the thyroid in papillary thyroid carcinoma (PTC). Fresh thyroid carcinoma tissue and paracarcinoma tissue were obtained from 34 patients undergoing surgery for PTC. The BRAF V600E mutation was detected by PCR amplification and direct DNA sequencing. The thyroid ultrasound results were compared between patients with and without the BRAF V600E mutation. Eighteen out of 34 cases were identified with the BRAF V600E mutation (52.9%), while 16 cases did not have the BRAF V600E mutation (47.1%). Additionally, no BRAF V600E mutation was detected in paracarcinoma tissue in the 34 cases. The results of ultrasound imaging suggested that there were no significant differences in tumor size, whether the border was clear, or in tumor calcification (presence or absence) between patients with and without BRAF V600E mutation (P0.05). The BRAF V600E mutation rate was high in patients with PTC. There was no significant correlation between BRAF V600E mutation and thyroid ultrasound features. Thyroid ultrasound features are therefore unable to predict the presence of the BRAF V600E mutation in patients with PTC.
机译：本研究的目的是探讨乳头状甲状腺癌（PTC）中甲状腺BRAF V600E突变和超声特征之间的关联。新鲜的甲状腺癌组织和剖腹产瘤组织是从接受PTC手术的34名患者获得的。通过PCR扩增和直接DNA测序检测BRAF V600E突变。在没有BRAF V600E突变的患者之间比较甲状腺超声结果。 34例中，34例均用BRAF V600E突变（52.9％）确定，而16例患者没有BRAF V600E突变（47.1％）。此外，在34例中，在剖腹产瘤组织中未检测到BRAF V600E突变。超声成像的结果表明，肿瘤大小没有显着差异，无论边界是否清晰，或者在没有BRAF v600E突变的患者之间的肿瘤钙化（存在或缺席）（p＆ 0.05）。 PTC患者BRAF V600E突变率高。 BRAF V600E突变和甲状腺超声特征之间没有显着相关性。因此，甲状腺超声特征不能预测PTC患者的BRAF V600E突变的存在。

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  • 来源
    《Oncology letters》 |2017年第1期|共6页
  • 作者

    Li Qian; Yuan Jianjun; Wang Yan; Zhai Yuanpeng;

  • 作者单位

    Zhengzhou Univ Dept Med Ultrason Henan Prov Peoples Hosp Peoples Hosp 7 Weiwu Rd Zhengzhou;

    Zhengzhou Univ Dept Med Ultrason Henan Prov Peoples Hosp Peoples Hosp 7 Weiwu Rd Zhengzhou;

    Zhengzhou Univ Dept Med Ultrason Affiliated Canc Hosp Zhengzhou 450008 Henan Peoples R China;

    Zhengzhou Univ Dept Med Ultrason Affiliated Canc Hosp Zhengzhou 450008 Henan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    papillary thyroid carcinoma; BRAF V600E; ultrasound;

    机译：乳头状甲状腺癌;BRAF V600E;超声波;

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