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首页> 外文期刊>Tissue engineering, Part A >High-frequency viscoelastic shear properties of vocal fold tissues: Implications for vocal fold tissue engineering
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High-frequency viscoelastic shear properties of vocal fold tissues: Implications for vocal fold tissue engineering

机译：声带组织的高频粘弹性剪切特性：对声带组织工程的启示

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The biomechanical function of the vocal folds (VFs) depends on their viscoelastic properties. Many conditions can lead to VF scarring that compromises voice function and quality. To identify candidate replacement materials, the structure, composition, and mechanical properties of native tissues need to be understood at phonation frequencies. Previously, the authors developed the torsional wave experiment (TWE), a stress-wave-based experiment to determine the linear viscoelastic shear properties of small, soft samples. Here, the viscoelastic properties of porcine and human VFs were measured over a frequency range of 10-200 Hz. The TWE utilizes resonance phenomena to determine viscoelastic properties; therefore, the specimen test frequency is determined by the sample size and material properties. Viscoelastic moduli are reported at resonance frequencies. Structure and composition of the tissues were determined by histology and immunochemistry. Porcine data from the TWE are separated into two groups: a young group, consisting of fetal and newborn pigs, and an adult group, consisting of 6-9-month olds and 2+-year olds. Adult tissues had an average storage modulus of 2309±1394 Pa and a loss tangent of 0.38±0.10 at frequencies of 36-200 Hz. The VFs of young pigs were significantly more compliant, with a storage modulus of 394±142 Pa and a loss tangent of 0.40±0.14 between 14 and 30 Hz. No gender dependence was observed. Histological staining showed that adult porcine tissues had a more organized, layered structure than the fetal tissues, with a thicker epithelium and a more structured lamina propria. Elastin fibers in fetal VF tissues were immature compared to those in adult tissues. Together, these structural changes in the tissues most likely contributed to the change in viscoelastic properties. Adult human VF tissues, recovered postmortem from adult patients with a history of smoking or disease, had an average storage modulus of 756±439 Pa and a loss tangent of 0.42±0.10. Contrary to the results of some other investigators, no significant frequency dependence was observed. This lack of observable frequency dependence may be due to the modest frequency range of the experiments and the wide range of stiffnesses observed within nominally similar sample types.
机译：声带（VF）的生物力学功能取决于它们的粘弹性。许多情况会导致VF结疤，从而损害语音功能和质量。为了识别候选替代材料，需要在发声频率下理解天然组织的结构，组成和机械性能。以前，作者开发了扭转波实验（TWE），这是一种基于应力波的实验，用于确定小的软样品的线性粘弹性剪切特性。在此，在10-200 Hz的频率范围内测量了猪和人VF的粘弹性。 TWE利用共振现象来确定粘弹性。因此，样品的测试频率取决于样品的大小和材料特性。在共振频率下报告了粘弹性模量。通过组织学和免疫化学确定组织的结构和组成。来自TWE的猪肉数据分为两组：一个年轻组，由胎猪和新生猪组成;一个成年组，由6-9个月大和2岁以上的年龄组成。成人组织在36-200 Hz频率下的平均储能模量为2309±1394 Pa，损耗角正切为0.38±0.10。幼猪的VF更加顺应，其储能模量为394±142 Pa，在14至30 Hz之间的损耗角正切为0.40±0.14。没有观察到性别依赖性。组织学染色显示，成年猪组织比胎儿组织具有更组织的分层结构，上皮更厚，固有层更结构化。与成人组织相比，胎儿VF组织中的弹性纤维还不成熟。在一起，组织中的这些结构变化最有可能促成粘弹性的变化。从具有吸烟或疾病史的成年患者的死后恢复的成年人类VF组织的平均储能模量为756±439 Pa，损耗角正切为0.42±0.10。与其他一些研究者的结果相反，没有观察到明显的频率依赖性。缺乏可观察到的频率依赖性可能是由于实验的频率范围适中，以及在名义上相似的样品类型中观察到的较宽的刚度范围。

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