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Toxicant-associated steatohepatitis

机译：毒物相关性脂肪性肝炎

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Hepatotoxicity is the most common organ injury due to occupational and environmental exposures to industrial chemicals. A wide range of liver pathologies ranging from necrosis to cancer have been observed following chemical exposures both in humans and in animal models. Toxicant-associated fatty liver disease (TAFLD) is a recently named form of liver injury pathologically similar to alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD). Toxicant-associated steatohepatitis (TASH) is a more severe form of TAFLD characterized by hepatic steatosis, inflammatory infiltrate, and in some cases, fibrosis. While subjects with TASH have exposures to industrial chemicals, such as vinyl chloride, they do not have traditional risk factors for fatty liver such as significant alcohol consumption or obesity. Conventional biomarkers of hepatotoxicity including serum alanine aminotransferase activity may be normal in TASH, making screening problematic. This article examines selected chemical exposures associated with TAFLD in human subjects or animal models and concisely reviews the closely related NAFLD and ALD.
机译：肝毒性是由于职业和环境暴露于工业化学品而引起的最常见的器官损伤。在人体和动物模型中进行化学暴露后，已观察到从坏死到癌症的各种肝脏病理。毒素相关性脂肪肝疾病（TAFLD）是一种最近命名的肝损伤形式，在病理学上类似于酒精性肝病（ALD）和非酒精性脂肪性肝病（NAFLD）。毒素相关性脂肪性肝炎（TASH）是一种更严重的TAFLD形式，其特征是肝脂肪变性，炎性浸润，在某些情况下还包括纤维化。尽管患有TASH的受试者接触过氯乙烯等工业化学品，但他们没有传统的脂肪肝危险因素，例如大量饮酒或肥胖。肝毒性的常规生物标志物（包括血清丙氨酸氨基转移酶活性）在TASH中可能是正常的，因此筛查存在问题。本文研究了人类受试者或动物模型中与TAFLD相关的选定化学暴露，并简要回顾了密切相关的NAFLD和ALD。

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