MCF-7 cells as a three-dimensional model for the study of human breast cancer.

do Amaral JB; Rezende Teixeira P; Freitas VM; Machado Santelli GM

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MCF-7 cells as a three-dimensional model for the study of human breast cancer.

机译：MCF-7细胞是研究人类乳腺癌的三维模型。

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The increasing use of three-dimensional (3D) cell culture is because it reproduces in vitro results similar to in vivo results. Multicellular tumor spheroids generated in vitro exhibit important characteristics of avascular tumors, mainly with respect to tumor physiology and microenvironment. The interaction among cells in a tridimensional culture environment enhances cell differentiation and leads to luminal formation in some breast-derived cell cultures. The present work describes a method that permits luminal formation in breast adenocarcinoma cell (MCF-7)-derived spheroids in a 3D environment. In the proposed model, several relevant parameters, such as cell survival, apoptosis, autophagy, and E-cadherin expression, were analyzed to understand the organization of MCF-7 cells during different culture phases, including luminal and bud formation.

机译：三维（3D）细胞培养物的使用越来越多，是因为它可以再现类似于体内结果的体外结果。体外产生的多细胞肿瘤球体显示出无血管肿瘤的重要特征，主要在肿瘤生理学和微环境方面。三维培养环境中细胞之间的相互作用增强了细胞分化，并导致某些乳腺细胞培养物中的腔形成。本工作描述了一种允许在3D环境中在乳腺腺癌细胞（MCF-7）衍生的球体中形成腔的方法。在提出的模型中，分析了几个相关参数，例如细胞存活率，凋亡，自噬和E-钙粘蛋白表达，以了解MCF-7细胞在不同培养阶段（包括腔和芽形成）的组织。

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《Tissue engineering, Part C. Methods》 |2011年第11期|共11页
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do Amaral JB; Rezende Teixeira P; Freitas VM; Machado Santelli GM;
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中图分类人体形态学;
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1. MCF-7 cells as a three-dimensional model for the study of human breast cancer. [J] . do Amaral JB, Rezende Teixeira P, Freitas VM, Tissue engineering, Part C. Methods . 2011,第11期

机译：MCF-7细胞是研究人类乳腺癌的三维模型。
2. Comparative Study of Lipophilic Statin Activity in 2D and 3D?in vitro Models of Human Breast Cancer Cell Lines MDA-MB-231 and MCF-7 [J] . Meda Bytautaite, Vilma Petrikaite OncoTargets and therapy . 2020,第2期

机译：2D和3D中亲脂肠病活性的对比研究？人乳腺癌细胞系MDA-MB-231和MCF-7的体外模型
3. Autocrine and paracrine actions of breast tumor aromatase. A three-dimensional cell culture study involving aromatase transfected MCF-7 and T-47D cells. [J] . Sun XZ, Zhou D, Chen S The Journal of Steroid Biochemistry and Molecular Biology . 1997,第1a3期

机译：乳腺芳香化酶的自分泌和旁分泌作用。涉及芳香酶转染的MCF-7和T-47D细胞的三维细胞培养研究。
4. Investigation of Intracrine Metabolism of Raloxifene and Tamoxifen in Ishikawa Human Endometrial Cell and MCF-7 Human Breast Cancer Cell Lines [C] . Gregory Gorman, Erika Cretton-Scott, Lori Coward, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：雷洛昔芬和西昔芬血红素人子宫内膜细胞和MCF-7人乳腺癌细胞系中肠道新陈代谢调查
5. Study of anti-cancer effect of winter worm and summer grass on MCF-7 human breast cancer cells. [D] . Xu, Tongtong. 2008

机译：冬虫夏草对MCF-7人乳腺癌细胞抗癌作用的研究。
6. Comparative Study of Lipophilic Statin Activity in 2D and 3D in vitro Models of Human Breast Cancer Cell Lines MDA-MB-231 and MCF-7 [O] . Meda Bytautaite, Vilma Petrikaite 2020

机译：二维乳腺癌细胞系MDA-MB-231和MCF-7体外模型中亲脂儿同三种体外模型的比较研究
7. Expression of the cytosolic phospholipase A2 isozymes in the human breast cancer cell line models MDA-MB 231 and MCF-7 and the normal breast cell line model MCF-10A [O] . Debolina Ganguly -1

机译：人乳腺癌细胞系中胞质磷脂酶A2同工酶的表达MDA-MB 231和MCF-7和正常乳腺细胞系模型MCF-10A

MCF-7 cells as a three-dimensional model for the study of human breast cancer.

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