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首页> 外文期刊>Toxicological sciences: An official journal of the Society of Toxicology >Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice.
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Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice.

机译：新生儿暴露于高溴化二苯醚，七，八或非溴二苯醚中会损害成年小鼠的自发行为和学习记忆功能。

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摘要

Polybrominated diphenyl ethers (PBDEs), used as flame retardants, have been shown to be increasing in the environment and in human mother's milk. We have earlier reported that lower brominated PBDEs, such as tetra-, penta-, and hexa-brominated diphenyl ethers, can cause developmental neurotoxic effects in mice. Recently, this was also observed with the full-brominated PBDE, deca-brominated diphenyl ether (PBDE 209), although it was suggested that the effects were caused by a (possibly debrominated) metabolite thereof. The present study revealed that 2,2',3,3',4,4',5,5',6-nonabromodiphenyl ether (PBDE 206), 2,2',3,4,4',5,5',6-octabromodiphenyl ether (PBDE 203), and to a minor extent also 2,2',3,4,4',5',6'-heptabromodiphenyl ether (PBDE 183) can induce developmental neurotoxic effects. Neonatal Naval Medical Research Institute male mice were exposed on postnatal day 3 or 10 to PBDE 206, PBDE 203, or PBDE 183, given as a single oral dose of 21 mumol/kg body weight. At the adult age of 2-3 months, the micewere observed for performance in a spontaneous behavior test and the Morris water maze test. PBDE 203 and PBDE 206, when administered on neonatal day 10, caused disturbances in spontaneous behavior, leading to disrupted habituation and a hyperactive condition in adults at the age of 2 months. These behavioral changes were also seen in 2-month-old mice exposed to PBDE 203 on neonatal day 3. Furthermore, exposure to PBDE 203 on neonatal day 10 affected learning and memory functions in adult mice. The developmental neurotoxic effects were most pronounced in mice exposed to PBDE 203. These developmental neurobehavioral defects were in agreement with those we observed previously with lower brominated PBDEs and with PBDE 209. It is important to consider the fact that different PBDE congeners can have differing degrees of potency, when comparing levels of PBDEs in the environment and in mother's milk.
机译：用作阻燃剂的多溴二苯醚（PBDEs）已证明在环境和人母乳中正在增加。我们之前已经报道过，低溴化的多溴二苯醚（例如四溴，五溴和六溴二苯醚）会在小鼠中引起发育性神经毒性作用。最近，尽管全溴化多溴二苯醚，十溴联苯醚（PBDE 209）也观察到了这一点，尽管有人认为这种影响是由其（可能是溴化的）代谢产物引起的。本研究表明2,2'，3,3'，4,4'，5,5'，6-九溴二苯醚（PBDE 206），2,2'，3,4,4'，5,5' ，6-八溴二苯醚（PBDE 203），在较小程度上也可以由2,2'，3,4,4'，5'，6'-七溴二苯醚（PBDE 183）诱导发育神经毒性作用。新生海军医学研究所的雄性小鼠在出生后第3天或第10天暴露于PBDE 206，PBDE 203或PBDE 183，单次口服剂量为21摩尔/千克体重。在2-3个月的成年年龄，在自发行为测试和莫里斯水迷宫测试中观察小鼠的表现。 PBDE 203和PBDE 206在新生儿第10天给药时，会导致自发性行为紊乱，导致2个月大的成年人出现习惯性紊乱和多动情况。在新生儿第3天暴露于PBDE 203的2个月大小鼠中也观察到了这些行为变化。此外，新生儿第10天暴露于PBDE 203的小鼠影响了成年小鼠的学习和记忆功能。在暴露于PBDE 203的小鼠中，发育神经毒性作用最为明显。这些发育神经行为缺陷与我们先前在低溴化PBDEs和PBDE 209中观察到的缺陷一致。重要的是要考虑不同的PBDE同源物可能具有不同程度的事实。比较环境和母乳中多溴二苯醚的水平时的功效。

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