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首页> 外文期刊>Toxicology in vitro: an international journal published in association with BIBRA >Design and characterisation of a novel in vitro skin diffusion cell system for assessing mass casualty decontamination systems
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Design and characterisation of a novel in vitro skin diffusion cell system for assessing mass casualty decontamination systems

机译：新型体外皮肤扩散池系统的设计和表征，用于评估大规模伤亡净化系统

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摘要

The efficient removal of contaminants from the outer surfaces of the body can provide an effective means of reducing adverse health effects associated with incidents involving the accidental or deliberate release of hazardous materials. Showering with water is frequently used by first responders as a rapid method of mass casualty decontamination (MCD). However, there is a paucity of data on the generic effectiveness and safety of aqueous decontamination systems. To address these issues, we have developed a new in vitro skin diffusion cell system to model the conditions of a common MCD procedure ("ladder pipe system"). The new diffusion cell design incorporates a showering nozzle, an air sampling port for measurement of vapour loss and/aerosolisation, adjustable (horizontal to vertical) skin orientation and a circulating manifold system (to maintain a specified flow rate, temperature and pressure of shower water). The dermal absorption characteristics of several simulants (Invisible Red S, curcumin and methyl salicylate) measured with the new in vitro model were in good agreement with previous in vitro and in vivo studies. Moreover, these initial studies have indicated that whilst flow rate and water temperature are important factors for MCD, the presence of clothing during showering may (under certain circumstances) cause transfer and spreading of contaminants to the skin surface.
机译：从身体外表面的有效去除污染物可以提供一种减少与意外或故意释放有害物质有关的不良健康影响的有效手段。急救人员经常使用淋浴水作为大规模伤亡消毒（MCD）的快速方法。但是，关于水净化系统的通用有效性和安全性的数据很少。为了解决这些问题，我们开发了一种新的体外皮肤扩散细胞系统，以模拟常见MCD程序的条件（“阶梯管系统”）。新的扩散池设计包括一个淋浴喷头，一个用于测量蒸汽损失和/或雾化的空气采样端口，可调节的（水平到垂直）皮肤方向以及一个循环歧管系统（以保持特定的流速，淋浴水的温度和压力） ）。用新的体外模型测定的几种模拟物（隐形红S，姜黄素和水杨酸甲酯）的皮肤吸收特性与先前的体外和体内研究非常吻合。此外，这些初步研究表明，尽管流速和水温是MCD的重要因素，但淋浴时衣物的存在（在某些情况下）可能导致污染物转移和扩散到皮肤表面。

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