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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >ortho-Phthalaldehyde enhances allergen-specific IgE production without allergen-specific IgG in ovalbumin-sensitized mice.
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ortho-Phthalaldehyde enhances allergen-specific IgE production without allergen-specific IgG in ovalbumin-sensitized mice.

机译：在卵白蛋白致敏的小鼠中，邻苯二甲醛可增强过敏原特异性IgE的产生，而无需过敏原特异性IgG。

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摘要

ortho-Phthalaldehyde (OPA) is commonly used as a safer and more effective chemical disinfectant for use with medical devices in hospitals. However, the cases of patients with occupational bronchial asthma or contact dermatitis are recently reported among workers in the medical professions who were exposed to OPA disinfectant. Mechanism of allergic reaction associated with OPA is poorly understood. The purpose of this study is that OPA may act as an immunological adjuvant in the allergic reaction accompanied by enhanced specific-IgE production in response to allergen challenge in OVA-sensitized mice. OPA induced increase of total cell numbers, and reflected infiltration of neutrophils in BAL fluid after allergen challenge in sensitized mice, dose-dependently. However, total protein concentration in BAL fluid did not change in the all of groups. The OPA induced up-regulation of eotaxin and monocyte chemotactic protein-1 mRNAs in the lung as well as the increase in OVA-specific IgE in sensitized mice compared with non-sensitized controlled mice without increase in the level of OVA-specific IgG. Cytokines IL-4 and IL-5 mRNA were expressed by allergen (OVA) challenge in both lungs collected from OPA-administrated-sensitized and OPA-administrated-nonsensitized mice. From these data, we concluded that low concentration of OPA that enhanced the OVA-induced recruitment of neutrophils to the lung and the production of allergen-specific IgE, suggesting that OPA acts as an immunological adjuvant.
机译：邻苯二甲醛（OPA）通常用作更安全，更有效的化学消毒剂，用于医院的医疗设备。但是，最近在医学专业工作人员中接触过OPA消毒剂的职业性支气管哮喘或接触性皮炎患者的报道。与OPA相关的过敏反应的机制了解甚少。这项研究的目的是，OPA可以在变态反应中作为免疫佐剂，对OVA致敏小鼠的变应原激发产生更高的特异性IgE产生。致敏小鼠在过敏原激发后，OPA诱导总细胞数增加，并反映中性粒细胞在BAL液中的浸润，呈剂量依赖性。但是，所有组中BAL液中的总蛋白浓度均未改变。与未致敏对照组相比，OPA诱导致敏小鼠肺中嗜酸性粒细胞趋化因子和单核细胞趋化蛋白-1 mRNA的上调以及OVA特异性IgE的增加，而OVA特异性IgG的水平却没有增加。过敏原（OVA）攻击在从OPA致敏小鼠和OPA致敏小鼠体内收集的肺中均表达了细胞因子IL-4和IL-5 mRNA。从这些数据中，我们得出结论，低浓度的OPA可以增强OVA诱导的中性粒细胞向肺的募集和过敏原特异性IgE的产生，这表明OPA可以作为免疫佐剂。

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