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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Effects of postnatal exposure to methylmercury on spatial learning and memory and brain NMDA receptor mRNA expression in rats.
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Effects of postnatal exposure to methylmercury on spatial learning and memory and brain NMDA receptor mRNA expression in rats.

机译：出生后甲基汞暴露对大鼠空间学习和记忆及脑NMDA受体mRNA表达的影响。

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摘要

The extreme vulnerability of developing nervous system to methylmercury (MeHg) is well documented. Still unclear is the consequence of different postnatal period exposure to MeHg. We investigated the critical postnatal phase when MeHg induced neurotoxicity in rats and the underlying mechanism. Rats were given 5mg/(kg day) methylmercury chloride (MMC) orally on postnatal day (PND) 7, PND14, PND28, and PND60 for consecutive 7 days. A control group was treated with 0.9% sodium chloride solution 5 ml/(kg day) instead. On PND69, spatial learning and memory was evaluated by Morris water maze test. Behavior deficits were found in MMC-treated rats of PND7 and PND14 groups (p<0.01). N-methyl-D-aspartate (NMDA) receptor 2 subunits mRNA expressions were evaluated 3 days after the last administration. In hippocampus, the mRNA expression of NR2A and NR2B decreased, but the NR2C expression increased in PND14 group following MMC-treatment (p<0.01). In cerebral cortex, mRNA expression of NR2A decreased, with NR2C expression elevating in PND14 group following MMC-treatment (p<0.05). These observations suggest that the postnatal exposure to MeHg during PND7-20 could cause neurobehavioral deficits which extend to adulthood. Furthermore, the abnormal expression of NMDAR 2 subunits might associate with the impairment.
机译：发展中的神经系统对甲基汞（MeHg）的极端脆弱性已有充分文献记载。尚不清楚的是，出生后不同时期暴露于甲基汞的后果。我们研究了MeHg诱导大鼠神经毒性时的关键产后阶段及其潜在机制。大鼠在出生后第7天，PND14，PND28和PND60连续7天口服5mg /（kg·day）氯化甲基汞（MMC）。对照组改为用0.9 ml氯化钠溶液5 ml /（kg·day）处理。在PND69上，通过Morris水迷宫测试评估了空间学习和记忆。在MMC治疗的PND7和PND14组的大鼠中发现了行为缺陷（p <0.01）。在最后一次给药后3天评估N-甲基-D-天冬氨酸（NMDA）受体2亚基的mRNA表达。在MMC处理后，PND14组海马的NR2A和NR2B的mRNA表达下降，但NR2C的表达增加（p <0.01）。在MMC处理后，PND14组的大脑皮层中，NR2A的mRNA表达降低，而NR2C的表达升高（p <0.05）。这些观察结果表明，PND7-20期间产后暴露于MeHg可能会导致神经行为缺陷，并延伸至成年期。此外，NMDAR 2亚基的异常表达可能与损伤有关。

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