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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Lack of histological cerebellar changes in Wistar rats given pulegone for 28 days. Comparison of immersion and perfusion tissue fixation.
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Lack of histological cerebellar changes in Wistar rats given pulegone for 28 days. Comparison of immersion and perfusion tissue fixation.

机译：Wistar大鼠给予pulegone 28天后，小脑组织学变化不明显。浸入和灌注组织固定的比较。

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摘要

Pulegone was given orally by gavage to groups of 28 SPF Wistar rats at dosage levels of 0 or 160 mg/kg body weight per day for 28 days. Clinically treated animals showed slackness, depression, decreased food consumption, and body weight. The loss of body weight was accompanied by a marked decrease in plasma creatinine. In contrast to earlier results, this study did not reveal occurrence of cyst-like spaces in the white matter of cerebellum using either perfusion or immersion tissue fixation techniques. Pulegone increased plasma alkaline phosphatase and relative liver weight indicating an adverse effect on the liver.
机译：通过管饲法向28只SPF Wistar大鼠组口服普勒高酮，剂量水平为每天0或160 mg / kg体重，持续28天。经临床治疗的动物表现出松弛，沮丧，食物消耗减少和体重下降。体重减轻伴随着血浆肌酐的显着降低。与早期结果相反，该研究未显示使用灌注或浸润组织固定技术在小脑白质中出现囊样样空间。 Pulegone增加血浆碱性磷酸酶和相对肝脏重量，表明对肝脏有不利影响。

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