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首页> 外文期刊>Journal of Neuroscience and Behavioral Health >Changes in behaviour, and cerebellar histology of Wistar rats exposed to refuse dump
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Changes in behaviour, and cerebellar histology of Wistar rats exposed to refuse dump

机译：暴露于垃圾场的Wistar大鼠的行为变化和小脑组织学

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Open waste dump sites are a common spectacle in Nigeria. These sites may cause neurotoxicity to people dwelling in their vicinity. Hence, the present study investigated the effects of long-term habitation at the vicinity of refuse dump sites on motor, mood and cognitive behaviours in rats, as well as on cerebellar histology. Young adult male Wistar rats, approximately 70 days old, were used for this study. Rats were housed in the vicinity of a refuse dump site for 8 months. At the end of 8 months rats were subjected to neurobehavioural studies in the open-field test (OFT), elevated-plus maze (EPM) and Morris water maze (MWM). Following behavioural studies, the cerebellum was excised and prepared for routine Hematoxylin and eosin (H&E) staining protocol. Results showed significant difference (p<0.05) on motor parameters of the OFT between exposed rats and control. Also, exposed rats showed significantly lower (P<0.05) % time in open arms on the EPM, and significantly higher (p<0.001) latency in the MWM. Histological studies revealed alterations to the cerebellar white core as well as degenerative changes of the Purkinje cells. This study therefore shows that long-term habitation in the vicinity of refuse dump site may be injurious to brain structures accompanied with behavioural defects.
机译：露天垃圾场在尼日利亚很常见。这些部位可能会对附近居民产生神经毒性。因此，本研究调查了在垃圾场附近长期居住对大鼠运动，情绪和认知行为以及小脑组织学的影响。这项研究使用了大约70天大的成年雄性Wistar大鼠。将大鼠饲养在垃圾场附近8个月。在8个月末，对大鼠进行了野外行为试验（OFT），高架迷宫（EPM）和莫里斯水迷宫（MWM）的神经行为研究。进行行为研究后，切除小脑并准备进行苏木精和曙红（H＆E）常规染色方案。结果显示，暴露的大鼠和对照组之间的OFT运动参数有显着差异（p <0.05）。同样，暴露的大鼠在EPM上张开双臂的时间显着缩短（P <0.05）％，而在MWM中显着更高的（p <0.001）潜伏期。组织学研究表明小脑白核的改变以及浦肯野细胞的退行性改变。因此，这项研究表明，在垃圾堆场附近长期居住可能会对伴随行为缺陷的大脑结构造成伤害。

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