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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Neurocysticercosis in children: clinical findings and response to albendazole therapy in a randomized, double-blind, placebo-controlled trial in newly diagnosed cases.
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Neurocysticercosis in children: clinical findings and response to albendazole therapy in a randomized, double-blind, placebo-controlled trial in newly diagnosed cases.

机译：儿童神经囊尾osis病：在新诊断病例中的一项随机，双盲，安慰剂对照试验中，临床发现和对阿苯达唑治疗的反应。

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摘要

The clinical findings of neurocysticercosis, diagnosed primarily on the basis of computed tomography (CT), and response to albendazole therapy in a randomized, double-blind, placebo-controlled trial were studied in 72 newly diagnosed children aged 1.5-12 years admitted to hospital in New Delhi, India, during March to July 2000. The lesions by initial CT were mostly single with perilesional oedema, and were located in the parietal lobes. The most common clinical finding was partial seizure (79.2%). The outcome of the albendazole trial was assessed through changes in CT lesions and status of seizure after 6 months of follow-up; about 55% of the lesions had disappeared and about 80% of the children were seizure-free. The frequency of healing of CT lesions in the albendazole-treated group and placebo group was 54.2% and 55.2%, respectively, and the frequency of a seizure-free state in the albendazole-treated group and placebo group was 87.5% and 77.5%, respectively; the differences were not statistically significant. Changes in lesions by CT and the recurrence of seizures after 6 months of follow-up were not related to the number of lesions by initial CT and albendazole was not beneficial in neurocysticercosis in children with ring-enhancing lesions in CT.
机译：在一项随机，双盲，安慰剂对照试验中，对72名年龄在1.5-12岁的新入院儿童进行了研究，主要基于计算机断层扫描（CT）诊断神经囊尾osis病的临床发现以及对阿苯达唑治疗的反应在印度新德里，于2000年3月至7月期间。最初的CT病变多为单一病灶周围水肿，位于顶叶。最常见的临床发现是部分发作（79.2％）。通过随访6个月后CT病变的变化和癫痫发作状态来评估阿苯达唑试验的结果;大约55％的病变消失了，大约80％的儿童没有癫痫发作。阿苯达唑治疗组和安慰剂组的CT损伤治愈率分别为54.2％和55.2％，阿苯达唑治疗组和安慰剂组的无癫痫发作频率分别为87.5％和77.5％，分别;差异无统计学意义。 CT引起的病变变化和随访6个月后癫痫发作的复发与最初CT引起的病变数量无关，阿苯达唑对CT环形增强病变的患儿的神经囊尾osis病无益。

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