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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Comparison of two single-day regimens of triclabendazole for the treatment of human pulmonary paragonimiasis.
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Comparison of two single-day regimens of triclabendazole for the treatment of human pulmonary paragonimiasis.

机译：比较三氯苯达唑单日治疗人肺吸虫病的方案。

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摘要

A well-tolerated single-day treatment regimen is required for the community-based treatment of pulmonary paragonimiasis. To identify an optimal single-day treatment regimen, an open clinical trial was performed to compare the efficacy of 2 single-day regimens of triclabendazole. From 1991 to 1993, a total of 154 Ecuadorian patients were allocated to receive either a single dose or 2 doses of 10 mg/kg triclabendazole. Treatment with both regimens was associated with a rapid parasitological response (determined by clearance of Paragonimus eggs from sputum), resolution of most clinical symptoms and radiological signs, and only mild adverse effects. At 3 months after treatment, the cure rate (clearance of eggs from sputum) was 90.9% in the 2-dose group and 84.4% in the single-dose group. Re-treatment with a second 2-dose regimen was curative in all remaining patients by 1 year of follow-up. Our findings show that both single-day treatment regimens of triclabendazole were highly effective in the treatment of pulmonary paragonimiasis and suggest that patients should be re-examined at 3 months to determine the need for repeat treatment.
机译：基于社区的肺吸虫病治疗需要良好耐受的单日治疗方案。为了确定最佳的单日治疗方案，进行了一项开放临床试验，以比较三氯苯达唑的两种单日方案的疗效。从1991年至1993年，总共154名厄瓜多尔患者被分配接受单剂或2剂10 mg / kg三氯苯达唑的治疗。两种方案的治疗均与快速的寄生虫学反应（取决于从痰液中清除Paragonimus卵），大多数临床症状和放射学症状的缓解以及仅轻微的不良反应有关。治疗3个月后，两剂组的治愈率（痰中卵清除率）为90.9％，单剂组为84.4％。随访1年，所有其余患者均接受第二次2剂量方案的重新治疗。我们的发现表明，三氯苯达唑的两种单日治疗方案在治疗肺吸虫病中均非常有效，建议应在3个月时对患者进行复查以确定是否需要重复治疗。

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