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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children
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Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children

机译：关于使用尿液CCA试纸检测学龄前儿童肠道血吸虫病的注意事项

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摘要

Urine-dipstick diagnostic tests that detect schistosome circulating cathodic antigen (CCA) have the potential to provide more sensitive and rapid testing for intestinal schistosomiasis in field-based surveys; this is especially so when examining preschool children, from whom it may be difficult to obtain consecutive stool samples. To assess the performance of urine dipsticks, 569 preschool children from four villages along the shore of Lake Albert, Uganda, were screened for Schistosoma mansoni by Kato-Katz (K-K) examination of a single stool sample and CCA urine dipsticks. The prevalence of infection was 32.2% by K-K and 40.0% by CCA tests. Sensitivity and specificity were influenced by whether 'trace' results from the CCA test were characterised as positive or negative for infection with S. mansoni; ambiguities around this issue need to be resolved. Nevertheless, the CCA test showed particular promise for routine epidemiological screening in this setting.
机译：用于检测血吸虫病的循环阴极抗原（CCA）的尿液量尺诊断测试有可能在基于现场的调查中为肠道血吸虫病提供更灵敏，更快速的测试;在检查学龄前儿童时尤其如此，从中很难连续获取粪便样本。为了评估尿液试纸的性能，对乌干达艾伯特湖沿岸四个村庄的569名学龄前儿童进行了一次单粪便样本和CCA尿液试纸的Kato-Katz（K-K）检查，筛查曼氏血吸虫。 K-K检测的感染率为32.2％，CCA检测的感染率为40.0％。敏感性和特异性受CCA测试的“痕量”结果表征为曼氏沙门氏菌感染的阳性或阴性的影响;有关此问题的歧义需要解决。尽管如此，CCA测试显示在这种情况下进行常规流行病学筛查特别有希望。

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