• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >The role of prothrombin time (PT) in evaluating green pit viper (Cryptelytrops sp) bitten patients
【24h】

The role of prothrombin time (PT) in evaluating green pit viper (Cryptelytrops sp) bitten patients

机译：凝血酶原时间（PT）在评估青坑毒蛇（Cryptelytrops sp）咬伤患者中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Viper bites cause consumptive coagulopathy resulting in hypofibrinogenaemia. Whole-blood clotting time is a standard test used to assess bleeding risk. Prothrombin time (PT) and activated partial thromboplastin time (APTT) are better standardised assays that are widely available, but their diagnostic accuracy in viper bites remains unknown. Adult patients presumed bitten by green pit vipers (. Cryptelytops sp.) were enrolled. Conventional venous clotting time (VCT), 20. min whole-blood clotting time (20WBCT), PT with international normalized ratio (INR) and APTT were determined. A fibrinogen level below 1.0. g/litre was used as the gold standard. There were 97 patients. The average age was 46.1 years and 49.5% were men. VCT >30. min, INR >1.2 and fibrinogen level <1.0. g/litre were found in 9.3, 10.3 and 7.2%, respectively. The sensitivities of VCT >30. min, 20WBCT (N. =. 55), INR and APTT were 57.0%, 85.7%, 85.7% and 57.1%, respectively. The respective specificities were 94.4%, 95.8%, 95.6% and 72.4%. Three hypofibrinogenaemic patients who did not receive antivenom because of VCT <30. min had persistently normal VCT and went home without clinical bleeding. In conclusion, PT with INR can be an alternative test for evaluation of coagulopathy in green pit viper bitten patients with potentially improved inter-laboratory standardisation.
机译：per蛇咬伤会引起消耗性凝血病，导致血纤维蛋白原性贫血。全血凝固时间是用于评估出血风险的标准测试。凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）是更好的标准化测定方法，已广泛使用，但它们在蛇咬伤中的诊断准确性仍然未知。假定成年患者被绿坑毒蛇（。Cryptelytops sp。）咬伤。确定了常规静脉凝血时间（VCT），20分钟全血凝血时间（20WBCT），具有国际标准化比率（INR）的PT和APTT。纤维蛋白原水平低于1.0。克/升用作金标准。有97例患者。平均年龄为46.1岁，男性为49.5％。 VCT> 30。最小，INR> 1.2，纤维蛋白原水平<1.0。克/升分别为9.3％，10.3％和7.2％。 VCT的灵敏度> 30。 min，20WBCT（N. = 55），INR和APTT分别为57.0％，85.7％，85.7％和57.1％。各自的特异性为94.4％，95.8％，95.6％和72.4％。三名低纤维蛋白原性血症患者因VCT <30而未接受抗蛇毒血清。分钟的VCT一直保持正常，并且没有临床出血就回家了。总之，PT与INR可以作为评估青坑蛇咬伤患者凝血功能障碍的替代测试，可能会改善实验室间的标准化水平。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号