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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Comparison of three copromicroscopic methods to assess albendazole efficacy against soil-transmitted helminth infections in school-aged children on Pemba Island.
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Comparison of three copromicroscopic methods to assess albendazole efficacy against soil-transmitted helminth infections in school-aged children on Pemba Island.

机译：三种辅助显微镜检查法评估阿苯达唑对奔巴岛学龄儿童土壤传播的蠕虫感染的疗效比较。

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摘要

The diagnostic accuracy of three faecal egg count techniques (Kato-Katz, McMaster and FLOTAC) to assess albendazole efficacy against soil-transmitted helminth (STH) infections was compared.The study is registered with Current Controlled Trials [identifier: ISRCTN90088840]. During September-November 2009, 304 school-aged children on Pemba Island, Tanzania, were screened and those infected with Ascaris lumbricoides, hookworm or Trichuris trichiura were treated with a single dose of albendazole (400 mg). Twenty-one days post-treatment, children provided a single stool sample which was examined using the same diagnostic methods. All stool samples were divided into two aliquots and one was fixed in 5% formalin and examined using FLOTAC and McMaster approximately 6 months after collection.Using fresh stool samples, comparable prevalences were demonstrated for the three methods at baseline (90-92.2% for T. trichiura, 41.1-52.8% for hookworm, 32.9-37.2% for A. lumbricoides); FLOTAC was the most sensitive method at baseline and follow-up. Albendazole showed high cure rate (CR) against A.?lumbricoides (90-97%), moderate CR against hookworm (63-72%) and very low CR against T.?trichiura (6-9%), regardless of the technique used. Egg counts (eggs per gram) at baseline were similar for A. lumbricoides and for hookworm among the three methods, and higher using McMaster and Kato-Katz compared with FLOTAC for T. trichiura. All methods were similar for hookworm and A. lumbricoides egg reduction rate (ERR) estimation, but Kato-Katz indicated a significantly higher ERR than McMaster and FLOTAC for T. trichiura. Preserved stool samples revealed consistently lower FECs at baseline and follow-up for all STHs.Further development and validation of standard protocols for anthelminthic drug efficacy evaluation must be pursued.
机译：比较了三种粪便卵计数技术（Kato-Katz，McMaster和FLOTAC）在评估阿苯达唑对土壤传播的蠕虫（STH）感染方面的诊断准确性。该研究已在“电流对照试验”中注册[标识符：ISRCTN90088840]。在2009年9月至11月期间，对坦桑尼亚奔巴岛的304名学龄儿童进行了筛查，对感染A虫，钩虫或Trichuris trichiura的儿童进行了单剂量阿苯达唑治疗（400毫克）。治疗后21天，儿童提供了一个粪便样本，并使用相同的诊断方法进行了检查。将所有粪便样本分为两等份，一份固定在5％福尔马林中，并在收集后约6个月使用FLOTAC和McMaster进行检查。使用新鲜粪便样本时，三种方法在基线时的患病率具有可比性（T值为90-92.2％ trichiura，钩虫为41.1-52.8％，A。lumbricoides为32.9-37.2％）; FLOTAC是基线和随访中最敏感的方法。无论采用哪种技术，阿苯达唑均对lum毛线虫的治愈率（CR）（90-97％），对钩虫的中等治愈率（63-72％）和对毛tri虫的CR极低（6-9％）。用过的。在三种方法中，A。lumbricoides和钩虫在基线时的卵数（每克蛋数）相近，而对于Trichiura T. trichoura，使用McMaster和Kato-Katz则高于FLOTAC。对于钩虫和A. lumbricoides减蛋率（ERR）估算，所有方法均相似，但Kato-Katz表明，对毛tri线虫的ERR明显高于McMaster和FLOTAC。保存的粪便样本显示所有STH的基线和随访时FEC始终较低，因此必须进一步开发和验证驱虫药疗效评估的标准方案。

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