首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Characterisation of predominant molecular patterns of Burkholderia pseudomallei in Taiwan.
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Characterisation of predominant molecular patterns of Burkholderia pseudomallei in Taiwan.

机译:台湾伯氏假单胞菌的主要分子模式的表征。

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摘要

The soil-dwelling pathogen Burkholderia pseudomallei is the cause of melioidosis. In this study, the geographical and temporal distributions of predominant molecular patterns occurring in clinical and environmental isolates of B. pseudomallei were characterised.A collection of 194 human and 59 soil B. pseudomallei isolates obtained in Taiwan were analysed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST).Five predominant PFGE types (VI, X, XI, XV and XVI) among human isolates were identified between 2004 and 2010. Among them, types VI, X and XI correspond to ST58, and types XV and XVI correspond to ST99. The distribution of B. pseudomallei with distinct PFGE or MLST types was clustered in different towns in southern Taiwan. Clusters of B. pseudomallei have successively appeared in the town of Jiading, which is located in the Er-Ren River Basin of southern Taiwan.Burkholderia pseudomallei isolates were geographically and temporally clustered in Taiwan. This finding supports the contention that the Er-Ren River Basin now constitutes the highest risk area for melioidosis in Taiwan.
机译:寄居土壤的病原体伯克霍尔德氏菌是类鼻疽病的病因。在这项研究中,表征了在临床和环境中分离到的假疟原虫的主要分子模式的地理和时间分布。通过脉冲场凝胶电泳分析了在台湾获得的194例人类和59例土壤假疟原虫的分离物( PFGE)和多基因座序列分型(MLST)。在2004年至2010年之间鉴定出人类分离株中五种主要的PFGE类型(VI,X,XI,XV和XVI)。其中,VI,X和XI类型分别对应于ST58和类型。 XV和XVI对应于ST99。 PFGE或MLST类型不同的假疟原虫的分布聚集在台湾南部的不同城镇。在台湾南部的二人河流域的嘉定镇中,出现了假疟原虫的集群。台湾假单胞菌的分离株在地理和时间上都聚集在台湾。这一发现支持了以下观点:二人流域现在是台湾地区类li虫病的最高风险地区。

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