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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection.
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Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection.

机译：阿根廷中部艾滋病毒感染成年人对抗逆转录病毒疗法的免疫学和病毒学应答的决定因素：丙型肝炎感染的负面影响。

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摘要

The purpose of this study was to update the epidemiological data on the prevalence of coinfection with hepatitis C virus (HCV) and HIV, and to identify whether specific clinical and epidemiological factors influenced the response of HIV-positive adults to highly active antiretroviral therapy (HAART).This retrospective observational cohort study of 238 HIV-infected patients evaluated the effect of different epidemiological and clinical parameters (including HCV coinfection) on therapy response among HIV-infected adults initiating HAART. Multiple logistic regression models were used to identify factors associated with therapy response and estimated risk coefficients.Seroprevalence of HCV infection in this population was 26% (62/238). We did not observe a significant association between immunological or virological response relating to patient gender or HAART regimen. However, this analysis showed that HCV serological status, age at HIV diagnosis, duration of treatment and WHO clinical stage of AIDS (<200 CD4 cells/ml independently of viral load either < or > to 100,000 copies/ml), were significantly associated with immunological and virological responses to HAART.These results show further evidence that hepatitis C serostatus is associated with a reduced response to HAART.
机译：这项研究的目的是更新有关丙型肝炎病毒（HCV）和HIV合并感染的流行病学数据，并确定特定的临床和流行病学因素是否影响HIV阳性成年人对高效抗逆转录病毒疗法的反应（HAART这项回顾性观察队列研究对238名HIV感染患者进行了评估，评估了不同流行病学和临床参数（包括HCV合并感染）对发起HAART的HIV感染成年人的治疗反应的影响。使用多个逻辑回归模型来确定与治疗反应和估计的风险系数相关的因素。该人群中HCV感染的血清阳性率为26％（62/238）。我们没有观察到与患者性别或HAART方案相关的免疫学或病毒学应答之间的显着关联。然而，该分析表明，HCV血清学状况，HIV诊断年龄，治疗时间和WHO临床分期（<200 CD4细胞/ ml，独立于病毒载量<或> 100,000拷贝/ ml）与以下因素显着相关：对HAART的免疫学和病毒学应答。这些结果进一步证明，丙型肝炎血清状况与对HAART的应答降低有关。

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