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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Profile and treatment outcomes of elderly patients with tuberculosis in Delhi, India: Implications for their management
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Profile and treatment outcomes of elderly patients with tuberculosis in Delhi, India: Implications for their management

机译：印度德里的老年结核病患者的概况和治疗结果：对其管理的启示

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Background: Given India's high rate of TB, rising burden of non-communicable diseases (NCDs) and growing elderly population, elderly TB patients may be at higher risk of adverse outcomes including death, loss-to-follow-up (LTFU) and treatment failure. This may call for modifications in their management. This study thus aimed to compare the profile and treatment outcomes between elderly (≥60 years) and non-elderly (15-59 years) TB patients. Methods: This was a retrospective cohort study using routinely-collected programme data from a chest clinic in Delhi, India. It included all elderly and selected non-elderly TB patients registered for treatment between 2005 and 2010. Data on patients' clinical and demographic characteristics and treatment outcomes were analysed. Results: There were 812 elderly and 1624 non-elderly TB patients. Elderly patients were more likely to be male (63.2% vs 51.1%) and have smear-positive TB (56.0% vs 47.4%). Adverse outcomes were more frequent among elderly patients (adjusted OR 1.9, 95% CI: 1.5-2.4), specifically deaths (adjusted OR 5.0, 95% CI: 3.1-8.1) and lost-to-follow-up (adjusted OR 1.4, 95% CI: 1.0-1.9). Conclusions: The profile and worse outcomes of elderly Indian TB patients may be indicative of co-existing NCDs. This needs further investigation and likely calls for a more comprehensive and intensive approach to their management.
机译：背景：鉴于印度的结核病发病率高，非传染性疾病（NCD）负担增加以及老年人口不断增加，老年结核病患者可能面临更高的不良后果风险，包括死亡，失访（LTFU）和治疗失败。这可能需要对其管理进行修改。因此，本研究旨在比较老年（≥60岁）和非老年（15-59岁）结核病患者的概况和治疗结果。方法：这是一项回顾性队列研究，使用了印度德里一家胸部诊所常规收集的程序数据。该研究包括所有在2005年至2010年期间登记接受治疗的老年和部分非老年TB患者。分析了患者的临床和人口统计学特征以及治疗结果的数据。结果：812例老年人和1624例非老年人结核病患者。老年患者更可能是男性（63.2％vs 51.1％）和涂片阳性结核病（56.0％vs 47.4％）。老年患者的不良结局更为频繁（校正后的OR 1.9，95％CI：1.5-2.4），尤其是死亡（校正后的OR 5.0，95％CI：3.1-8.1）和失访（校正后的OR 1.4， 95％CI：1.0-1.9）。结论：老年印度结核病患者的病情和预后较差可能表明存在非传染性疾病。这需要进一步调查，并且可能需要对其管理采取更全面，更深入的方法。

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