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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Complex genetic structure of the rabies virus in Bangkok and its surrounding provinces, Thailand: implications for canine rabies control.
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Complex genetic structure of the rabies virus in Bangkok and its surrounding provinces, Thailand: implications for canine rabies control.

机译：泰国曼谷及其周边省份狂犬病病毒的复杂遗传结构：对犬狂犬病控制的影响。

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摘要

Dog vaccination and population management have been suggested as priorities in attempts at disease control in canine rabies-endemic countries. Budget limitations and the complexity of social, cultural and religious variables have complicated progress in the developing world. In Bangkok, Thailand, an intensive canine vaccination and sterilization programme has been in place since November 2002. Our objective was to determine if the rabies virus could be mapped according to its genetic variations and geographical location on the small localized scale of Bangkok and its surrounding provinces. Phylogenetic characterization of 69 samples from Bangkok and five neighbouring and two remote provinces, by limited sequence analysis of the rabies virus nucleoprotein gene, distinguished six different clades. Rabies viruses of four clades were intermixed in Bangkok and in the surrounding highly populated regions whereas the other two clades were confined to rural and less populated provinces. Such a complex pattern of gene flow, particularly in Bangkok, may affect the outcome of canine control programmes.
机译：在犬狂犬病流行国家，已建议将狗的疫苗接种和种群管理作为疾病控制的重点。预算的限制以及社会，文化和宗教变量的复杂性使发展中世界的进展复杂化。自2002年11月起，在泰国曼谷实施了密集的犬疫苗接种和绝育计划。我们的目标是确定狂犬病病毒是否可以根据其遗传变异和地理位置在曼谷及其周边地区的小范围内进行定位省。通过对狂犬病病毒核蛋白基因的有限序列分析，对曼谷及邻近的五个省和两个偏远省份的69个样品进行了系统发育鉴定，从而区分出六个进化枝。曼谷和周围人口稠密地区混有四个进化枝的狂犬病病毒，而其他两个进化枝则仅限于农村和人口稀少的省份。这种复杂的基因流动模式，尤其是在曼谷，可能会影响犬类控制计划的结果。

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