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首页> 外文期刊>Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides >Development of liposomal Ganoderma lucidum polysaccharide: Formulation optimization and evaluation of its immunological activity
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Development of liposomal Ganoderma lucidum polysaccharide: Formulation optimization and evaluation of its immunological activity

机译：脂质体灵芝多糖的开发：配方优化及其免疫活性评估

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摘要

The aim of this study was to investigate the optimizing preparation conditions of Ganoderma lucidum polysaccharide liposome (GLPL) with response surface methodology (RSM) and the immunological enhancement activity of GLPL. The immunological enhancement activity of GLPL on splenocyte proliferation was measured. The optimum formulation of GLPL, in which the ratio of soybean phospholipid to cholesterol( w/w) of 11:1, the ratio of soybean phospholipid to tween-80 (w/w) of 10.5:1 and ultrasonic time(min) of 11, had higher entrapment efficiency (EE) of 71.43 +/- 0.49% with spherical shape and uniform sizes. In addition, GLPL could significantly promote splenocyte proliferation singly or synergistically with PHA and LPS. That indicated that the immunological enhancement of Ganoderma lucidum polysaccharide (GLP) was significantly enhanced after encapsulation with the liposome. (C) 2014 Elsevier Ltd. All rights reserved.
机译：本研究的目的是利用响应面法（RSM）研究灵芝多糖脂质体（GLPL）的优化制备条件和GLPL的免疫增强活性。测量了GLPL对脾细胞增殖的免疫增强活性。 GLPL的最佳配方，其中大豆磷脂与胆固醇的比（w / w）为11：1，大豆磷脂与吐温80的比（w / w）为10.5：1，超声波时间（min）为11，具有球形和均匀尺寸的更高的包封效率（EE）为71.43 +/- 0.49％。此外，GLPL可以与PHA和LPS单独或协同显着促进脾细胞增殖。这表明用脂质体包封后，灵芝多糖（GLP）的免疫学增强显着增强。 （C）2014 Elsevier Ltd.保留所有权利。

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