Research and Development of a Ganoderma lucidum Polysaccharide Injection Formulation

机译：灵芝多糖注射剂的研制

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The aim of this study was to investigate the effect of injecting polysaccharides from Ganoderma lucidum into hosts for clinical practice. The polysaccharide aqueous extracts of Ganoderma lucidum' s fruit body was purified by Deproteinization of Sevage method, anion-exchange chromatography elution, dialysis, ethanol precipitation, active carbon filter, and millipore membrane filter technique. The injection was prepared from purified Ganoderma lucidum polysaccharide (GLPS). Polysaccharide indexes, protein, tannin, heavy metal, arsenic salt, oxalate, potassium ion, resin, pH, ignition residue, evaluation criterion of allergic reaction, total solids content of the GLPS injection were all tested with the reference method in Chinese Pharmacopoeia (2010ed). The results showed that the key component of injection was polysaccharide, ignition residue and total solids content were 1.4% and 2. 4%, respectively, the other indices were all within expected safety ranges. Notably, the injection improved the antifatigue capacity of mice with no effect in weight.

机译：这项研究的目的是研究将灵芝多糖注射入宿主的临床实践效果。灵芝子实体的多糖水提物采用Sevage脱蛋白法，阴离子交换色谱法洗脱，透析，乙醇沉淀，活性炭过滤和微孔膜过滤技术进行纯化。注射剂由纯化的灵芝多糖（GLPS）制备。 GLPS注射液的多糖指标，蛋白质，单宁，重金属，砷盐，草酸盐，钾离子，树脂，pH，灼烧残渣，过敏反应评估标准，总固体含量均通过《中国药典》（2010年版）。结果表明，注射剂的主要成分为多糖，着火残留物和总固体含量分别为1.4％和2. 4％，其他指标均在预期的安全范围内。值得注意的是，该注射剂改善了小鼠的抗疲劳能力，而对体重没有影响。

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来源
《Proceedings of the 18th congress of the International Society for Mushroom Science》|2012年|567-573|共7页
会议地点 Beijing(CN)
作者
Yuji Jiang; Anle He; Baogui Xie; Ye Li; Youjin Deng; Xinrui Liu;
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作者单位

College of Food Science Mycological Research Center, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China;

College of Food Science;

Mycological Research Center, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China;

Fujian Xianzhilou Biological Science Technology Co. , Ltd, Fuzhou, Fujian,China;

Mycological Research Center, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China;

Mycological Research Center, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China;

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原文格式 PDF
正文语种 eng
中图分类菌类（食用菌）;
关键词
Ganoderma lucidum; Polysaccharide; Purification; Injection;

机译：灵芝;多糖;纯化;注射剂;

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1. Development of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) Polysaccharides Injection Formulation [J] . Jiang Yuji, He Anle, Liu Yanhong, International Journal of Medicinal Mushrooms . 2014,第5期

机译：灵芝或灵芝药用蘑菇，灵芝（高级担子菌）多糖注射剂的研制
2. Development of liposomal Ganoderma lucidum polysaccharide: Formulation optimization and evaluation of its immunological activity [J] . Liu Zhenguang, Ma Xia, Deng Bihua, Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides . 2015,第Null期

机译：脂质体灵芝多糖的开发：配方优化及其免疫活性评估
3. Quantification of total polysaccharides and triterpenoids in Ganoderma lucidum and Ganoderma atrum by near infrared spectroscopy and chemometrics [J] . Yi Chen, Mingyong Xie, Hui Zhang, Food Chemistry . 2012,第1期

机译：利用近红外光谱和化学计量学对灵芝和灵芝中的总多糖和三萜类化合物进行定量
4. Research and Development of a Ganoderma lucidum Polysaccharide Injection Formulation [C] . Yuji Jiang, Anle He, Baogui Xie, Congress of the International Society for Mushroom Science . 2012

机译：Ganoderma lucidum多糖注射配方的研究与开发
5. Formulation development and in-vitro evaluation of a polysaccharide-based colon-specific drug delivery system (CSDDS) for the treatment of inflammatory bowel disease. [D] . Singh, Brahma N. 2003

机译：基于多糖的结肠特异性药物传递系统（CSDDS）的配方开发和体外评估，用于治疗炎症性肠病。
6. Development of an Efficient Strategy to Improve Extracellular Polysaccharide Production of Ganoderma lucidum Using L-Phenylalanine as an Enhancer [O] . Zhongbao Ma, Mengmeng Xu, Qiong Wang, -1

机译：使用L-苯丙氨酸作为增强剂改善灵芝细胞外多糖生产的有效策略的开发
7. Development of an Efficient Strategy to Improve Extracellular Polysaccharide Production of Ganoderma lucidum Using L-Phenylalanine as an Enhancer [O] . Zhongbao Ma, Mengmeng Xu, Qiong Wang, 2019

机译：一种高效策略，以改善使用L-苯丙胺作为增强剂的Ganoderma Lucidum的细胞外多糖产生

Research and Development of a Ganoderma lucidum Polysaccharide Injection Formulation

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