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首页> 外文期刊>Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems >Thymoquinone blocks lung injury and fibrosis by attenuating bleomycin-induced oxidative stress and activation of nuclear factor Kappa-B in rats.
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Thymoquinone blocks lung injury and fibrosis by attenuating bleomycin-induced oxidative stress and activation of nuclear factor Kappa-B in rats.

机译：胸腺醌可通过减弱博来霉素诱导的氧化应激和激活核因子κB来阻断肺损伤和纤维化。

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摘要

Pulmonary fibrosis is one of the most common chronic interstitial lung diseases with high mortality rate after diagnosis and limited successful treatment. The present study was designed to assess the potential antifibrotic effect of thymoquinone (TQ) and whether TQ can attenuate the severity of oxidative stress and inflammatory response during bleomycin-induced pulmonary fibrosis. Male Wister rats were treated intraperitoneally with either bleomycin (15 mg/kg, 3 times a week for 4 weeks) and/or thymoquinone (5mg/kg/day, 1 week before and until the end of the experiment). Bleomycin significantly increased lung weight and the levels of Lactate dehydrogenase, total leucocytic count, total protein and mucin in bronchoalveolar lavage and these effects were significantly ameliorated by TQ treatment. As markers of oxidative stress, bleomycin caused a significant increase in the levels of lipid peroxides and nitric oxide accompanied with a significant decrease in the antioxidant enzyme activity of superoxide dismutase and glutathione transferase. TQ treatment restored these markers toward normal values. TQ also counteracted emphysema in air alveoli, inflammatory cell infiltration, lymphoid hyperplastic cells activation surrounding the bronchioles and the over expression of activated form of nuclear factor kappa-B (NF-B) in lung tissue that was induced by bleomycin. Fibrosis was assessed by measuring hydroxyproline content, which increased markedly in the bleomycin group and significantly reduced by concurrent treatment with TQ. Furthermore, histopathological examination confirmed the antifibrotic effect of TQ. Collectively these findings indicate that TQ has potential antifibrotic effect beside its antioxidant activity that could be through NF-κB inhibition.
机译：肺纤维化是最常见的慢性间质性肺疾病之一，诊断后死亡率高，治疗成功率有限。本研究旨在评估胸腺醌（TQ）的潜在抗纤维化作用，以及TQ是否可以减弱博来霉素诱导的肺纤维化过程中氧化应激和炎症反应的严重性。用博来霉素（15 mg / kg，每周3次，共4周）和/或胸腺醌（5mg / kg /天，实验前1周和直到实验结束）每周腹膜处理雄性Wister大鼠。博来霉素显着增加了肺重量，支气管肺泡灌洗液中的乳酸脱氢酶，总白细胞计数，总蛋白和粘蛋白水平显着提高，而TQ处理可明显改善这些影响。作为氧化应激的标志物，博来霉素引起脂质过氧化物和一氧化氮的水平显着增加，同时超氧化物歧化酶和谷胱甘肽转移酶的抗氧化酶活性显着降低。 TQ处理使这些标记恢复正常值。 TQ还抵消了肺泡中的肺气肿，炎性细胞浸润，细支气管周围的淋巴样增生细胞活化以及由博来霉素诱导的肺组织中核因子κB（NF-B）活化形式的过度表达。通过测量羟脯氨酸含量评估纤维化，羟脯氨酸含量在博来霉素组中显着增加，而同时接受TQ治疗则明显降低。此外，组织病理学检查证实了TQ的抗纤维化作用。这些发现共同表明，TQ除具有抗氧化活性外，还具有潜在的抗纤维化作用，这可能是通过抑制NF-κB引起的。

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