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首页> 外文期刊>Transactions of the American Ophthalmological Society. >The therapy of amblyopia: an analysis comparing the results of amblyopia therapy utilizing two pooled data sets.
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The therapy of amblyopia: an analysis comparing the results of amblyopia therapy utilizing two pooled data sets.

机译：弱视治疗：利用两个汇总数据集比较弱视治疗结果的分析。

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CONTEXT: We previously presented the results of an original pooled data set of 961 amblyopic patients who underwent patching therapy for amblyopia from 1965 to 1994 (study group 1). Three types of amblyopia were considered: anisometropic, anisometropic-strabismic, and strabismic. Analysis of this group's success was related to the age at which therapy was initiated, the type of amblyopia, and the depth of visual loss before treatment was begun. The purpose of the current study is to test the validity of these findings on a second group of 961 amblyopes employing the data set used by Woodruff and associates in their publications (study group 2). These 2 data sets, after adjustment to conform to the definitions of age, amblyopia, anisometropia, and similar items utilized in common between the 2 study groups, will be compared for the risk factors predictive of successful occlusion therapy. OUTCOME: As in the previous study, the success of occlusion therapy is defined as a visual acuity of 20/40 or better at the end of treatment. RESULTS: Success by the 20/40 criteria was achieved in 73.7% in study group 1 and in 59.9% in study group 2. By category, the rate of success in study group 1 was 77.2% in strabismic amblyopia, 67.2% in anisometropic-strabismic amblyopia, and 66.0% in anisometropic amblyopia. In study group 2, success was 61.2% in strabismic amblyopia, 51.2% in anisometropic-strabismic amblyopia, and 63.0% in anisometropic amblyopia. Study group 1 univariate analysis related success in each group to the age at which therapy was initiated, the type of amblyopia, and the depth of visual loss before treatment in each group. In study group 2, univariate analysis related success of occlusion therapy to age and the depth of visual loss before treatment. Type of amblyopia was not related to outcome success in this group. When the 2 data sets were pooled, the risk factors for success were age and depth of visual loss at onset of treatment. CONCLUSIONS: Factors that appeared closely related to a successful outcome of patching therapy were patient age and depth of visual loss before treatment. These conclusions further support the value of early detection and screening for amblyopia, its prevention, where possible, and its adequate and vigorous treatment when it is detected and diagnosed.
机译：语境：我们先前介绍了1965年至1994年间接受弱视修补治疗的961名弱视患者的原始汇总数据集（研究组1）。考虑了三种类型的弱视：屈光参差性，屈光参差性斜视和斜视。该组成功的分析与开始治疗的年龄，弱视的类型以及治疗开始之前视力下降的深度有关。本研究的目的是使用伍德拉夫及其同事在其出版物中使用的数据集（研究组2），对第二组961弱视进行这些检验的有效性。调整以符合年龄，弱视，屈光参差和两个研究组之间共同使用的类似项目的定义后，将这两个数据集进行比较，以预测成功闭塞治疗的危险因素。结果：与之前的研究一样，闭塞治疗的成功定义为治疗结束时的视敏度为20/40或更高。结果：研究组1的73.7％和研究组2的59.9％达到了20/40标准的成功率。按类别，斜视性弱视中研究组1的成功率为77.2％，屈光参差性弱视的成功率为67.2％。斜视性弱视，屈光参差性弱视占66.0％。在研究组2中，斜视性弱视成功率为61.2％，屈光参差性斜视性弱视成功率为51.2％，屈光参差性弱视成功率为63.0％。第1研究组的单因素分析将每组的成功与开始治疗的年龄，弱视的类型以及治疗前视力丧失的深度相关。在研究组2中，单因素分析将闭塞治疗的成功与年龄和治疗前视力丧失的深度相关。该组弱视类型与预后是否成功无关。汇总这两个数据集后，成功的风险因素是治疗开始时的年龄和视力丧失深度。结论：与修补治疗成功结果密切相关的因素是患者年龄和治疗前视力减退的深度。这些结论进一步支持了对弱视的早期发现和筛查，在可能的情况下进行预防以及在发现和诊断时进行充分而有力的治疗的价值。

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