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首页> 外文期刊>Translational research: the journal of laboratory and clinical medicine >Targeting inflammation in metabolic syndrome
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Targeting inflammation in metabolic syndrome

机译：靶向代谢综合征中的炎症

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摘要

The metabolic syndrome (MetS) is comprised of a cluster of closely related risk factors, including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high-density lipoprotein cholesterol; all of which increase the risk for the development of type 2 diabetes and cardiovascular disease. A chronic state of inflammation appears to be a central mechanism underlying the pathophysiology of insulin resistance and MetS. In this review, we summarize recent research which has provided insight into the mechanisms by which inflammation underlies the pathophysiology of the individual components of MetS including visceral adiposity, hyperglycemia and insulin resistance, dyslipidemia, and hypertension. On the basis of these mechanisms, we summarize therapeutic modalities to target inflammation in the MetS and its individual components. Current therapeutic modalities can modulate the individual components of MetS and have a direct anti-inflammatory effect. Lifestyle modifications including exercise, weight loss, and diets high in fruits, vegetables, fiber, whole grains, and low-fat dairy and low in saturated fat and glucose are recommended as a first line therapy. The Mediterranean and dietary approaches to stop hypertension diets are especially beneficial and have been shown to prevent development of MetS. Moreover, the Mediterranean diet has been associated with reductions in total and cardiovascular mortality. Omega-3 fatty acids and peroxisome proliferator-activated receptor alpha agonists lower high levels of triglyceride; their role in targeting inflammation is reviewed. Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and aldosterone blockers comprise pharmacologic therapies for hypertension but also target other aspects of MetS including inflammation. Statin drugs target many of the underlying inflammatory pathways involved in MetS.
机译：代谢综合症（MetS）由一系列密切相关的风险因素组成，包括内脏肥胖，胰岛素抵抗，高血压，高甘油三酯和低高密度脂蛋白胆固醇。所有这些都会增加患2型糖尿病和心血管疾病的风险。炎症的慢性状态似乎是胰岛素抵抗和MetS的病理生理基础的主要机制。在这篇综述中，我们总结了最近的研究，这些研究为炎症奠定了MetS各个组成部分的病理生理基础的机理的见解，这些机理包括内脏肥胖，高血糖和胰岛素抵抗，血脂异常和高血压。在这些机制的基础上，我们总结了针对MetS及其单个成分中炎症的治疗方法。当前的治疗方式可以调节MetS的各个组成部分，并具有直接的抗炎作用。建议一线疗法，包括运动，减肥和富含水果，蔬菜，纤维，全谷物和低脂乳制品，低饱和脂肪和葡萄糖的饮食，以改善生活方式。地中海和饮食上停止高血压饮食的方法特别有益，并且已经证明可以预防MetS的发展。此外，地中海饮食与总死亡率和心血管死亡率的降低有关。 Omega-3脂肪酸和过氧化物酶体增殖物激活的受体α激动剂可降低高甘油三酸酯水平;综述了它们在靶向炎症中的作用。血管紧张素转换酶抑制剂，血管紧张素受体阻滞剂和醛固酮阻滞剂不仅可以治疗高血压，还可以靶向MetS的其他方面，包括炎症。他汀类药物靶向许多与MetS相关的潜在炎症途径。

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