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首页> 外文期刊>Translational research: the journal of laboratory and clinical medicine >Effects of fine carbonaceous particles containing high and low unpaired electron spin densities on lungs of female mice.
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Effects of fine carbonaceous particles containing high and low unpaired electron spin densities on lungs of female mice.

机译：含高和低未成对电子自旋密度的碳质细颗粒对雌性小鼠肺的影响。

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摘要

The negative impacts on human health that accompany inhalation of atmospheric particles are documented in numerous epidemiologic studies, but the effect of specific chemical properties of the particles is generally unknown. We developed and employed technology for generating inhalable aerosols of carbonaceous air pollution particles that have specific physical and chemical properties. We find that inhaling particles with greater unpaired electron spin (free radical) densities stimulates greater lung inflammatory and oxidative stress responses. Cultured alveolar macrophages take up more particles of greater free radical content, develop mitochondrial abnormalities, and release more leukotriene B(4) (LTB(4)) than alveolar macrophages exposed to lesser free-radical-containing particles in vitro. Mice exposed to high free radical particles in vivo also develop mitochondrial abnormalities in alveolar macrophages and increased oxidative stress, which is reflected by increases in lung nitrotyrosine staining and lung lavage nitrogen oxide levels compared with those of lesser free radical density. These results provide insight for the unexplained geographic differences and have implications for fossil fuel combustion conditions and the impact of fine particles on health and disease.
机译：大量流行病学研究表明，大气颗粒吸入会给人类健康带来负面影响，但通常尚不知道颗粒特定化学性质的影响。我们开发并采用了产生具有特定物理和化学特性的可吸入碳质空气污染颗粒气溶胶的技术。我们发现，具有更大的不成对电子自旋（自由基）密度的吸入颗粒会刺激更大的肺部炎症和氧化应激反应。培养的肺泡巨噬细胞比体外暴露于自由基含量较低的颗粒的肺泡巨噬细胞吸收更多的自由基含量更高的颗粒，发生线粒体异常，并释放出更多的白三烯B（4）（LTB（4））。体内暴露于高自由基颗粒的小鼠也会在肺泡巨噬细胞中发生线粒体异常，并增加氧化应激，这与较低自由基密度的肺硝基酪氨酸染色和肺灌洗氮氧化物水平相比有所增加。这些结果为无法解释的地理差异提供了见识，并且对化石燃料的燃烧条件以及细颗粒对健康和疾病的影响具有影响。

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