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首页> 外文期刊>Translational research: the journal of laboratory and clinical medicine >Integrating genomic and clinical medicine: searching for susceptibility genes in complex lung diseases.
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Integrating genomic and clinical medicine: searching for susceptibility genes in complex lung diseases.

机译：整合基因组和临床医学：寻找复杂肺部疾病的易感基因。

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The integration of molecular, genomic, and clinical medicine in the post-genome era provides the promise of novel information on genetic variation and pathophysiologic cascades. The current challenge is to translate these discoveries rapidly into viable biomarkers that identify susceptible populations and into the development of precisely targeted therapies. In this article, we describe the application of comparative genomics, microarray platforms, genetic epidemiology, statistical genetics, and bioinformatic approaches within examples of complex pulmonary pathobiology. Our search for candidate genes, which are gene variations that drive susceptibility to and severity of enigmatic acute and chronic lung disorders, provides a logical framework to understand better the evolution of genomic medicine. The dissection of the genetic basis of complex diseases and the development of highly individualized therapies remain lofty but achievable goals.
机译：后基因组时代的分子，基因组和临床医学的整合提供了有关遗传变异和病理生理级联的新颖信息的希望。当前的挑战是将这些发现迅速转化为可识别易感人群的可行生物标记，并发展为精确靶向的疗法。在本文中，我们描述了复杂的肺部病理生物学实例中比较基因组学，微阵列平台，遗传流行病学，统计遗传学和生物信息学方法的应用。我们对候选基因的搜索，这些基因是导致对神秘的急性和慢性肺部疾病易感性和严重性的基因变异，为更好地了解基因组医学的发展提供了逻辑框架。解剖复杂疾病的遗传基础和发展高度个性化疗法仍然是崇高但可实现的目标。

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