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首页> 外文期刊>Transactions of the American Ophthalmological Society. >THE ROLE OF OMEGA-3 DIETARY SUPPLEMENTATION IN BLEPHARITIS AND MEIBOMIAN GLAND DYSFUNCTION (AN AOS THESIS)
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THE ROLE OF OMEGA-3 DIETARY SUPPLEMENTATION IN BLEPHARITIS AND MEIBOMIAN GLAND DYSFUNCTION (AN AOS THESIS)

机译：OMEGA-3膳食补充剂在小盲症和睑板腺功能障碍中的作用（AOS论文）

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摘要

Purpose: Blepharitis and meibomian gland dysfunction (MGD) are common sources of complaints from patients. To evaluate the effect on ocular symptoms, ocular findings, and serum and meibomian gland contents, patients with blepharitis and MGD were prospectively evaluated to determine the effects of dietary supplementation with omega-3 fatty acids. Methods: In a prospective randomized placebo-controlled masked trial, patients with simple obstructive MGD and blepharitis, who had discontinued all topical medications and tetracyclines, received oral omega-3 dietary supplementation consisting of two 1000-mg capsules 3 times a day. Patients were examined every 3 months for 1 year with the Ocular Surface Disease Index (OSDI) objective clinical measures, including tear production and stability, ocular surface and meibomian gland health, and biochemical plasma, red blood cell (RBC), and meibum evaluation. Primary outcome measures were change in tear breakup time (TBUT), meibum score, and overall OSDI score at 1 year. Results: At 1 year, the omega-3 group had a 36% and 31% reduction in their omega-6 to omega-3 fatty acid ratios in RBCs and plasma, respectively (P = .3), whereas the placebo group demonstrated no change. At 12 months, the omega-3 group had an improvement in TBUT, OSDI score, and meibum score. Changes in meibum content were observed in the omega-3 group (P = .21); the level of meibum saturated fatty acids decreased. Conclusions: This trial demonstrated a decrease in the RBC and plasma ratios of omega-6 to omega-3 in patients taking omega-3 dietary supplementation, as compared to controls, and improvements in their overall OSDI score, TBUT, and meibum score. This is the first demonstration of an induced change in the fatty acid saturation content in meibum as a result of dietary supplementation with omega-3 fatty acids.
机译：目的：睑缘炎和睑板腺功能障碍（MGD）是患者抱怨的常见来源。为了评估对眼部症状，眼部检查结果以及血清和睑板腺含量的影响，前瞻性评估了睑缘炎和MGD患者以确定补充omega-3脂肪酸的饮食效果。方法：在一项前瞻性随机安慰剂对照的蒙面试验中，已停用所有局部用药和四环素的单纯性梗阻性MGD和睑缘炎患者，口服欧米伽3膳食补充剂，每天两次，每次两次，剂量为1000 mg胶囊。使用眼表疾病指数（OSDI）客观临床指标对患者每3个月进行1年检查，包括眼泪产生和稳定性，眼表和睑板腺健康以及生化血浆，红细胞（RBC）和睑缘评估。主要结局指标为1年时眼泪破裂时间（TBUT），胫骨评分和OSDI总体评分的变化。结果：在1年时，omega-3组的RBC和血浆中的omega-6与omega-3脂肪酸比率分别降低了36％和31％（P = .3），而安慰剂组没有表现出更改。在12个月时，omega-3组的TBUT，OSDI评分和睑板评分均有改善。在omega-3组中观察到胫骨含量的变化（P = 0.21）;胫骨饱和脂肪酸水平降低。结论：该试验表明，与对照组相比，补充omega-3饮食的患者的RBC和omega-6与omega-3的血浆比率降低，并且其总OSDI得分，TBUT和睑板得分得到改善。这是由于膳食补充omega-3脂肪酸而引起的睑板脂肪酸饱和度诱导变化的首次证明。

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