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首页> 外文期刊>Transactions of the American Ophthalmological Society. >ANTI-CYCLIC CITRULLINATED PEPTIDE, RHEUMATOID FACTOR, AND OCULAR SYMPTOMS TYPICAL OF RHEUMATOID ARTHRITIS
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ANTI-CYCLIC CITRULLINATED PEPTIDE, RHEUMATOID FACTOR, AND OCULAR SYMPTOMS TYPICAL OF RHEUMATOID ARTHRITIS

机译：类风湿关节炎的抗循环全肽，类风湿因子和典型症状

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Purpose: To correlate the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies and rheumatoid factor (RF) with ocular symptoms typical of rheumatoid arthritis (RA). Methods: The records of 451 patients who had been examined by an ophthalmologist and tested for anti-CCP antibodies over a 3-year period at the Mayo Clinic were reviewed. Records of 255 patients with titers of anti-CCP and RF were analyzed for ocular surface and inflammatory disease associated with ocular RA. Results: Of the 33 anti-CCP+/RF+ patients, all were diagnosed with RA; ocular surface disease was present in 11 (33%) and inflammatory disease in 7 (21%). Of the 17 anti-CCP-/RF+ patients, 4 were diagnosed with an unspecified inflammatory arthritis and 1 with rheumatoid arthritis; a separate 5 (29%) had ocular surface disease. Out of 5 anti-CCP+/RF- patients, 3 were diagnosed with RA but none had ocular symptoms. Out of 200 anti-CCP-/RF- patients, 32 (16%) had ocular surface disease and 2 (1%) had ocular inflammation. Of the 74 patients diagnosed with any form of inflammatory arthritis, anti-CCP+/RF+ patients had more and worse inflammatory ocular RA disease compared to the other groups. Conclusions: Patients who were both anti-CCP and RF positive tended to have more and worse ocular disease. In patients diagnosed with an inflammatory arthritis, the presence of anti-CCP antibodies and RF provides useful information to ophthalmologists for identifying patients most at risk for inflammatory ocular disease.
机译：目的：将抗环瓜氨酸肽（anti-CCP）抗体和类风湿因子（RF）的存在与类风湿关节炎（RA）的典型眼部症状相关联。方法：回顾了在Mayo诊所进行了为期3年的检查的451名患者的记录，这些患者经过眼科医生检查并检测了抗CCP抗体。分析了255例具有抗CCP和RF滴度的患者的眼表和与眼RA相关的炎性疾病的记录。结果：33例抗CCP + / RF +患者中，均被确诊为RA。眼表疾病占11（33％），炎性疾病占7（21％）。在17例抗CCP- / RF +患者中，有4例被诊断为未明确的炎性关节炎，而1例被诊断为类风湿性关节炎;另有5名（29％）患有眼表疾病。在5例抗CCP + / RF-患者中，有3例被确诊为RA，但没有眼部症状。在200名抗CCP- / RF-患者中，32名（16％）患有眼表疾病，2名（1％）患有眼部炎症。在被诊断患有任何形式的炎症性关节炎的74名患者中，抗CCP + / RF +患者与其他组相比，患有更多和更严重的炎症性眼RA疾病。结论：同时抗CCP和RF阳性的患者往往有更多和更严重的眼部疾病。在被诊断患有炎性关节炎的患者中，抗CCP抗体和RF的存在为眼科医生提供了有用的信息，可用于确定最有可能患有炎性眼病风险的患者。

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