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首页> 外文期刊>Transactions of the American Ophthalmological Society. >Histopathologic analysis of palpebral conjunctiva in thyroid-related orbitopathy (an american ophthalmological society thesis).
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Histopathologic analysis of palpebral conjunctiva in thyroid-related orbitopathy (an american ophthalmological society thesis).

机译：甲状腺相关性眼眶病变中睑结膜的组织病理学分析（美国眼科学会论文）。

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To examine the histopathology of palpebral conjunctiva in patients with thyroid-related orbitopathy. Based on previously published anecdotes, the hypothesis is that conjunctiva shows increased inflammation and fibrosis.This was a comparative case series. Superior palpebral conjunctiva was examined from two groups. The study group consisted of 20 patients undergoing thyroid-related upper eyelid retraction surgery. The control group consisted of 18 patients undergoing ptosis repair. Specimens were processed and stained using hematoxylin and eosin and trichrome. Histopathologic grading was performed using light microscopy. Main outcome measures were degree of inflammation and fibrosis, mast cell infiltration, and fibroblast count.The two groups did not differ with regard to age or gender. Mean degree of inflammation was 1.4 (95% CI: 0.9, 1.9) for the control group and 1.7 (95% CI: 1.3, 2.1) for the study group. Relative intensity of blue from trichrome staining mean was 134.3 (95% CI: 130.3, 138.3) for the control group and 138.6 (95% CI: 133.7, 143.6) for the study group. The Mann-Whitney test showed no difference between groups in inflammation (P=.17), relative blue intensity (P=.11), degree of mast cell infiltration (P=.61), and fibroblast count (P=.45). Point estimates show a trend toward greater inflammation in the study group.While there is a trend toward higher inflammation in the study group, the superior palpebral conjunctiva of patients with thyroid-related orbitopathy is largely spared from autoimmune changes. This has implications in surgical approaches to eyelid retraction repair.
机译：要检查甲状腺相关眼眶病患者睑结膜的组织病理学。根据以前发表的轶事，假说是结膜显示炎症和纤维化增加，这是一个比较病例系列。从两组检查上睑结膜。该研究组由20例接受甲状腺相关的上眼睑牵开手术的患者组成。对照组由18名接受上睑下垂修复的患者组成。使用苏木精，曙红和三色染料对样品进行处理和染色。使用光学显微镜进行组织病理学分级。主要结局指标为炎症和纤维化程度，肥大细胞浸润和成纤维细胞计数。两组在年龄或性别上没有差异。对照组的平均炎症程度为1.4（95％CI：0.9，1.9），研究组为1.7（95％CI：1.3，2.1）。相对于三色染色平均值，对照组的蓝色相对强度为134.3（95％CI：130.3，138.3），研究组为138.6（95％CI：133.7，143.6）。 Mann-Whitney测试显示，炎症（P = .17），相对蓝色强度（P = .11），肥大细胞浸润程度（P = .61）和成纤维细胞计数（P = .45）在两组之间没有差异。 。点估计值显示研究组的炎症趋向于较高。研究组的炎症趋于于较高，但是甲状腺相关性眼病患者的上睑结膜在很大程度上免于自身免疫改变。这对眼睑回缩修复的外科手术方法有影响。

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