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首页> 外文期刊>Transfusion medicine >Transfusion-related acute lung injury caused by two donors with anti-human leucocyte antigen class II antibodies: a look-back investigation.
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Transfusion-related acute lung injury caused by two donors with anti-human leucocyte antigen class II antibodies: a look-back investigation.

机译：由两个供体使用抗人类白细胞抗原II类抗体引起的与输血相关的急性肺损伤：回顾研究。

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摘要

Transfusion-related acute lung injury (TRALI) is considered as one of the most important complications of blood transfusion. Previous look-back investigations have revealed unrecognized cases. We report two cases of TRALI in brief and the outcomes of transfusion in the recipients of previous components from the implicated donors. This look-back investigation was a retrospective case-note study assessing whether there were any untoward events associated with the previous transfusions. 18 patients were identified as having received a blood component transfusion from one of the two donors with anti-human leucocyte antigen (HLA) antibodies to antigens occurring frequently in the local population. One of the five patients receiving a unit of fresh frozen plasma had an evidence of TRALI, which was not diagnosed at the time. A second patient, who had been HLA typed and who carried a full match of antigens for the antibody specificities of the plasma received, had no evidence of a reaction. There were no documented reactions in 13 recipients of red cells in optimal additive (OA) solution. Cases of TRALI may go unrecognized. Not all patients with antibody/antigen concordance will develop clinical signs. Red cells in OA solution from donors with anti-HLA antibodies appear to have a low risk of causing clinically evident lung damage.
机译：与输血有关的急性肺损伤（TRALI）被认为是输血最重要的并发症之一。先前的回顾调查发现了无法识别的案件。我们简要报告了两例TRALI病例以及牵连的捐助者先前成分的接受者的输血结果。这项回顾性研究是一项回顾性案例研究，旨在评估以前的输血是否有不良事件。鉴定出18名患者已接受来自两个供体之一的血液成分输注的抗人白细胞抗原（HLA）抗体，以抗当地人群中频繁发生的抗原。在接受一单位新鲜冷冻血浆的五名患者中，有一位患有TRALI证据，当时并未被诊断。第二名患者是HLA型，携带的抗原与所接收血浆的抗体特异性完全匹配，没有证据表明有反应。在最佳添加剂（OA）溶液中，没有13名红细胞受体的反应记录。 TRALI的病例可能无法识别。并非所有具有抗体/抗原一致性的患者都会出现临床体征。来自捐献者的抗HLA抗体的OA溶液中的红细胞看来引起临床上明显的肺损伤的风险较低。

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