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首页> 外文期刊>Transfusion medicine reviews >National Institutes of Health State of the Science Symposium in Therapeutic Apheresis: Scientific Opportunities in Extracorporeal Photopheresis
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National Institutes of Health State of the Science Symposium in Therapeutic Apheresis: Scientific Opportunities in Extracorporeal Photopheresis

机译：美国国立卫生研究院治疗针灸科学状况研讨会：体外光透疗法的科学机会

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The clinical use of extracorporeal photopheresis (ECP) for accepted indications such as graft-versus-host disease, transplant rejection, and cutaneous T-cell lymphoma continues to increase. Expanded applications for ECP, such as the treatment of select autoimmune diseases, are being explored. Extracorporeal photopheresis's capacity to both immunotolerize in the autoreactive setting, while immunizing against a lymphoma is unusual and suggestive of a unique mechanism. It is likely that ECP's induction of dendritic cells is key to its efficacy in both of these settings, but exactly how ECP impacts other immune components and their interactions is not fully understood. Further basic science research is necessary to elucidate how these dissimilar cellular activities are functionally integrated. On the clinical side, collaborative multicenter trials designed to recognize the principal variables controlling therapeutic responses and improve prognostic indicators may enable tailoring devices, treatment schedules, and doses to the needs of the individual patients or diseases. This review describes our current understanding of how ECP influences the immune system, reviews the existing clinical applications of ECP, and explores areas for future basic science and clinical research as presented at the National Institutes of Health State of the Science Symposium in Therapeutic Apheresis in November 2012. Published by Elsevier Inc.
机译：体外光透疗法（ECP）在诸如移植物抗宿主病，移植排斥和皮肤T细胞淋巴瘤等公认适应症中的临床应用不断增加。正在探索ECP的扩展应用，例如某些自身免疫性疾病的治疗。体外光透疗法在自身反应性环境中既能免疫耐受又能抵抗淋巴瘤免疫的能力是不寻常的，并暗示了其独特的机制。在这两种情况下，ECP对树突状细胞的诱导可能是其功效的关键，但是，ECP究竟如何影响其他免疫成分及其相互作用尚不清楚。需要进一步的基础科学研究来阐明这些异种细胞活动如何在功能上整合。在临床方面，旨在识别控制治疗反应和改善预后指标的主要变量的协作性多中心试验可以根据患者或疾病的具体情况定制设备，治疗方案和剂量。这篇综述描述了我们目前对ECP如何影响免疫系统的理解，回顾了ECP的现有临床应用，并探讨了如美国国家卫生研究院11月在美国国家治疗疗法科学研讨会上介绍的未来基础科学和临床研究领域。 2012年。ElsevierInc.发行。

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