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首页> 外文期刊>Transfusion: The Journal of the American Association of Blood Banks >Preterm birth and the availability of cord blood for HPC transplantation.
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Preterm birth and the availability of cord blood for HPC transplantation.

机译：早产和可用于HPC移植的脐带血。

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BACKGROUND: Cord blood from deliveries at term can be used for HPC transplantation. The objective of this study was to determine the amounts of cord blood nucleated cells (NCs) and HPCs that were collectable from preterm deliveries. STUDY DESIGN AND METHODS: Cord blood collected from preterm deliveries between 22 and 36 weeks of gestation was compared with regard to volume, NC count (/mL), CD34+ cell count (/mL), and the NC and CD34+ cell counts per cord blood sample and at different gestational ages. RESULTS: A correlation was found between gestational age and NC count (r = 0.52, p<0.001), and an inverse relation was found between gestational age and CD34+ cell count (r = - 0.68, p<0.001). The CD34+ cell count per cord blood sample was independent of gestational age (r = - 0.13, p = NS), and no significant difference between early (22-32 week) and late (33-36 week) preterm deliveries was found (p = 0.870). Comparison with published data from cord blood transplantations revealed that up to one-third of preterm samples contained at least as many NCs (or CD34+ cells) as the median cell dose transplanted (calculated for the median recipient weight) in the respective study. Furthermore, 77 percent of all preterm samples contained at least 1 x 10(7) NCs (and 42% at least 1 x 10(5) CD34+ cells) per kg for transplantation in a recipient of 20-kg body weight, which corresponds to the lower threshold of cells per kg in the graft recommended by Eurocord. CONCLUSION: Preterm delivery should not be a reason to exclude cord blood collection if allogeneic cord blood transplantation in a sibling is planned.
机译：背景：足月分娩的脐带血可用于HPC移植。这项研究的目的是确定可从早产中收集的脐带血有核细胞（NCs）和HPC的数量。研究设计和方法：比较了从妊娠22至36周的早产中收集的脐带血的体积，NC计数（/ mL），CD34 +细胞计数（/ mL）以及每个脐带血的NC和CD34 +细胞计数样本和不同的胎龄。结果：胎龄与NC计数之间存在相关性（r = 0.52，p <0.001），胎龄与CD34 +细胞计数之间呈负相关（r =-0.68，p <0.001）。每个脐带血样本的CD34 +细胞计数与胎龄无关（r =-0.13，p = NS），早产（22-32周）和晚期（33-36周）之间无显着差异（p = 0.870）。与来自脐带血移植的已发表数据的比较表明，多达三分之一的早产儿样本所含的NCs（或CD34 +细胞）至少与相应研究中移植的中位细胞剂量（以中位受体重量计算）一样多。此外，所有早产样品中有77％每千克包含至少1 x 10（7）个NCs（42％至少1 x 10（5）CD34 +细胞），可移植到20 kg体重的受者体内，相当于Eurocord建议的移植物中每公斤细胞的较低阈值。结论：如果计划在同胞中进行异基因脐带血移植，早产不应成为排除脐带血收集的理由。

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