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首页> 外文期刊>Trends in Plant Science >Plant cell factories in the post-genomic era: new ways to produce designer secondary metabolites.
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Plant cell factories in the post-genomic era: new ways to produce designer secondary metabolites.

机译:后基因组时代的植物细胞工厂:产生设计师次级代谢产物的新方法。

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摘要

Plants synthesize an extensive array of secondary metabolites, often with highly complex structures. Currently, most pharmaceutically important secondary metabolites are isolated from wild or cultivated plants because their chemical synthesis is not economically feasible. Biotechnological production in plant cell cultures is an attractive alternative, but to date this has had only limited commercial success because of a lack of understanding of how these metabolites are synthesized. Here, we discuss how the spectacular advances in plant genomics and metabolite profiling offer unprecedented possibilities to explore the extraordinary complexity of the plant biochemical capacity. State-of-the art genomics tools can be used to enhance the production of known target metabolites or to synthesize entire novel compounds by so-called combinatorial biochemistry in cultivated plant cells.
机译:植物合成大量次级代谢产物,通常具有高度复杂的结构。当前,大多数药学上重要的次生代谢产物是从野生或栽培植物中分离出来的,因为它们的化学合成在经济上是不可行的。植物细胞培养中的生物技术生产是一种有吸引力的替代方法,但是由于缺乏对这些代谢物的合成方法的了解,迄今为止,这种方法在商业上仅取得了有限的成功。在这里,我们讨论植物基因组学和代谢物谱分析的惊人进展如何为探索植物生化能力的非凡复杂性提供前所未有的可能性。先进的基因组学工具可用于通过培养植物细胞中的所谓组合生物化学来增强已知目标代谢产物的产生或合成整个新型化合物。

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