Cytogenetics as a tool to study gene regulation [Review]

Tessadori F; van Driel R; Fransz P

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Cytogenetics as a tool to study gene regulation [Review]

机译：细胞遗传学作为研究基因调控的工具[综述]

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Cell identity is determined by the nuclear program and established by a complex molecular interplay between DNA sequence and proteins. The past few years have witnessed major breakthroughs in the elucidation of this intricate mechanism of epigenetic gene regulation. Covalent modifications in cytosine residues of DNA and in histone tails are revealed as hallmarks that establish the functional status of chromatin domains. In particular, our knowledge of the functional implication of histone tail modifications, known as the histone code, has rapidly increased. Cytogenetics has taken a prominent share in this expanding research field by linking nuclear structures with biochemical features such as gene activity, DNA replication, histone modification and DNA methylation. This review summarizes the role of cytogenetics in exploring the mechanism underlying higher order gene regulation.

机译：细胞身份由核程序决定，并由DNA序列和蛋白质之间复杂的分子相互作用建立。在过去的几年中，在阐明这种复杂的表观遗传基因调控机制方面取得了重大突破。 DNA的胞嘧啶残基和组蛋白尾巴中的共价修饰被揭示为建立染色质结构域功能状态的标志。尤其是，我们对组蛋白尾部修饰的功能含义（称为组蛋白代码）的了解迅速增加。通过将核结构与生物化学特征（如基因活性，DNA复制，组蛋白修饰和DNA甲基化）联系起来，细胞遗传学已在这一扩展的研究领域中占有重要份额。这篇综述总结了细胞遗传学在探索高阶基因调控机制中的作用。

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《Trends in Plant Science》 |2004年第3期|共7页
作者
Tessadori F; van Driel R; Fransz P;
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正文语种 eng
中图分类植物学;
关键词
Histone h3 methyltransferase; Scale chromatin organization; Human; transcriptome map; Dna methylation; Chromosome territories; Arabidopsis-thaliana; Interphase nuclei; Lysine-9 methylation; Mammalian-cells; Expressed genes;

机译：组蛋白h3甲基转移酶;染色质组织;人类;转录组图;Dna甲基化;染色体区域;拟南芥;间期核;赖氨酸9甲基化;哺乳动物细胞;表达基因;

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1. Cytogenetics as a tool to study gene regulation [Review] [J] . Tessadori F, van Driel R, Fransz P Trends in Plant Science . 2004,第3期

机译：细胞遗传学作为研究基因调控的工具[综述]
2. The use of cytogenetic tools for studies in the crop-to-wild gene transfer scenario [J] . E. Benavente, M. Cifuentes, J.C. Dusautoir, Cytogenetic and genome research . 2008,第3a4期

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3. Utilization of cytogenetic biomarkers as a tool for assessment of radiation injury and evaluation of radiomodulatory effects of various medicinal plants – a review [J] . Ravindra M Samarth, Meenakshi Samarth, Yoshihisa Matsumoto Drug Design, Development and Therapy . 2015,第9期

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4. Molecular cytogenetics as a diagnostic tool for typing melanocytic tumors. [C] . Bastian BC World Congress on Cancers of the Skin . 2002

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Cytogenetics as a tool to study gene regulation [Review]

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